Title | Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Day FR, Thompson DJ, Helgason H, et al. |
Secondary Authors | Perry JRB |
Corporate Authors | LifeLines Cohort Study, InterAct Consortium, kConFab/AOCS Investigators, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, PRACTICAL Consortium |
Journal | Nat Genet |
Volume | 49 |
Issue | 6 |
Pagination | 834-841 |
Date Published | 2017 Jun |
ISSN | 1546-1718 |
Keywords | Adolescent, Age Factors, Body Mass Index, Calcium-Binding Proteins, Databases, Genetic, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomic Imprinting, Humans, Intercellular Signaling Peptides and Proteins, Male, Membrane Proteins, Menarche, Neoplasms, Polymorphism, Single Nucleotide, Puberty, Quantitative Trait Loci, Ribonucleoproteins, Risk Factors |
Abstract | The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 independent signals (P |
DOI | 10.1038/ng.3841 |
Alternate Journal | Nat Genet |
PubMed ID | 28436984 |
PubMed Central ID | PMC5841952 |
Grant List | SP/07/008/24066 / BHF_ / British Heart Foundation / United Kingdom MC_UU_12015/2 / MRC_ / Medical Research Council / United Kingdom 14136 / CRUK_ / Cancer Research UK / United Kingdom G0401527 / MRC_ / Medical Research Council / United Kingdom MC_UU_12013/1 / MRC_ / Medical Research Council / United Kingdom UM1 CA182913 / CA / NCI NIH HHS / United States MC_UU_12013/5 / MRC_ / Medical Research Council / United Kingdom Z01 AG006000-01 / ImNIH / Intramural NIH HHS / United States 10124 / CRUK_ / Cancer Research UK / United Kingdom MR/N003284/1 / MRC_ / Medical Research Council / United Kingdom MC_UU_12013/3 / MRC_ / Medical Research Council / United Kingdom G1000143 / MRC_ / Medical Research Council / United Kingdom MR/J012165/1 / MRC_ / Medical Research Council / United Kingdom MC_EX_MR/L100002/1 / MRC_ / Medical Research Council / United Kingdom R56 AG029451 / AG / NIA NIH HHS / United States G1001357 / MRC_ / Medical Research Council / United Kingdom MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom P2C HD050924 / HD / NICHD NIH HHS / United States T32 HL007055 / HL / NHLBI NIH HHS / United States R01 CA192393 / CA / NCI NIH HHS / United States |