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Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.

TitleGenomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
Publication TypeJournal Article
Year of Publication2017
AuthorsDay FR, Thompson DJ, Helgason H, et al.
Secondary AuthorsPerry JRB
Corporate AuthorsLifeLines Cohort Study, InterAct Consortium, kConFab/AOCS Investigators, Endometrial Cancer Association Consortium, Ovarian Cancer Association Consortium, PRACTICAL Consortium
JournalNat Genet
Volume49
Issue6
Pagination834-841
Date Published2017 Jun
ISSN1546-1718
KeywordsAdolescent, Age Factors, Body Mass Index, Calcium-Binding Proteins, Databases, Genetic, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomic Imprinting, Humans, Intercellular Signaling Peptides and Proteins, Male, Membrane Proteins, Menarche, Neoplasms, Polymorphism, Single Nucleotide, Puberty, Quantitative Trait Loci, Ribonucleoproteins, Risk Factors
Abstract

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 independent signals (P

DOI10.1038/ng.3841
Alternate JournalNat Genet
PubMed ID28436984
PubMed Central IDPMC5841952
Grant ListSP/07/008/24066 / BHF_ / British Heart Foundation / United Kingdom
MC_UU_12015/2 / MRC_ / Medical Research Council / United Kingdom
14136 / CRUK_ / Cancer Research UK / United Kingdom
G0401527 / MRC_ / Medical Research Council / United Kingdom
MC_UU_12013/1 / MRC_ / Medical Research Council / United Kingdom
UM1 CA182913 / CA / NCI NIH HHS / United States
MC_UU_12013/5 / MRC_ / Medical Research Council / United Kingdom
Z01 AG006000-01 / ImNIH / Intramural NIH HHS / United States
10124 / CRUK_ / Cancer Research UK / United Kingdom
MR/N003284/1 / MRC_ / Medical Research Council / United Kingdom
MC_UU_12013/3 / MRC_ / Medical Research Council / United Kingdom
G1000143 / MRC_ / Medical Research Council / United Kingdom
MR/J012165/1 / MRC_ / Medical Research Council / United Kingdom
MC_EX_MR/L100002/1 / MRC_ / Medical Research Council / United Kingdom
R56 AG029451 / AG / NIA NIH HHS / United States
G1001357 / MRC_ / Medical Research Council / United Kingdom
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
P2C HD050924 / HD / NICHD NIH HHS / United States
T32 HL007055 / HL / NHLBI NIH HHS / United States
R01 CA192393 / CA / NCI NIH HHS / United States