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Diabetes status modifies the association between carotid intima-media thickness and incident heart failure: The Atherosclerosis Risk in Communities study.

TitleDiabetes status modifies the association between carotid intima-media thickness and incident heart failure: The Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2017
AuthorsEffoe VS, McClendon EE, Rodriguez CJ, Wagenknecht LE, Evans GW, Chang PP
Secondary AuthorsBertoni AG
JournalDiabetes Res Clin Pract
Volume128
Pagination58-66
Date Published2017 Jun
ISSN1872-8227
KeywordsAtherosclerosis, Carotid Intima-Media Thickness, Diabetes Mellitus, Type 2, Female, Heart Failure, Humans, Male, Middle Aged, Risk Factors
Abstract

AIMS: Increasing carotid intima-media thickness (CIMT) is associated with incident heart failure (HF). We investigated whether this association differs by diabetes status.

METHODS: We characterized 13,590 Atherosclerosis Risk in Communities Study participants free of baseline HF into normal fasting glucose (NFG, glucose

RESULTS: T2D participants had higher mean CIMT (0.79±0.20mm), compared to IFG (0.75±0.19mm) and NFG (0.70±0.17mm) (p

CONCLUSIONS: CIMT is associated with increased risk of HF, particularly among persons without diabetes. Due to a high absolute risk of HF among adults with T2D, CIMT may be a less reliable predictor.

DOI10.1016/j.diabres.2017.04.009
Alternate JournalDiabetes Res Clin Pract
PubMed ID28448893
PubMed Central IDPMC5501651
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States