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Physical Activity, Obesity, and Subclinical Myocardial Damage.

TitlePhysical Activity, Obesity, and Subclinical Myocardial Damage.
Publication TypeJournal Article
Year of Publication2017
AuthorsFlorido R, Ndumele CE, Kwak L, Pang Y, Matsushita K, Schrack JA, Lazo M, Nambi V, Blumenthal RS, Folsom AR, Coresh JJ, Ballantyne CM
Secondary AuthorsSelvin E
JournalJACC Heart Fail
Date Published2017 05
KeywordsAge Factors, Aged, Biomarkers, Body Mass Index, Cardiomyopathies, Cohort Studies, Confidence Intervals, Exercise, Female, Humans, Male, Middle Aged, Obesity, Odds Ratio, Prognosis, Prospective Studies, Reference Values, Severity of Illness Index, Sex Factors, Troponin T

OBJECTIVES: This study sought to evaluate the association of physical activity with chronic myocardial damage, assessed by elevated high-sensitivity cardiac troponin T (hs-cTnT), in individuals with and without obesity.

BACKGROUND: Physical activity is associated with reduced risk of heart failure (HF), particularly among obese people. The role of chronic myocardial damage in this association is uncertain.

METHODS: We studied 9,427 participants in the Atherosclerosis Risk in Communities Study without cardiovascular disease, with body mass index >18.5 kg/m. Physical activity was categorized per American Heart Association guidelines as recommended, intermediate, or poor. We evaluated cross-sectional associations of physical activity and obesity with elevated hs-cTnT (≥14 ng/l). In prospective analyses, we quantified the association of elevated hs-cTnT with HF risk within cross-categories of baseline physical activity and obesity.

RESULTS: People with poor physical activity were more likely to have elevated hs-cTnT than those with recommended levels (odds ratio [OR]: 1.39; 95% confidence interval [CI]: 1.15 to 1.68). In cross-categories of physical activity and obesity, using the non-obese/recommended activity group as the reference, individuals with obesity and poor activity were most likely to have elevated hs-cTnT (OR: 2.46; 95% CI: 1.91 to 3.19), whereas the obese/recommended activity group had a weaker association (OR: 1.68; 95% CI: 1.28 to 2.21; p  0.20 for interaction).

CONCLUSIONS: Physical activity is inversely associated with chronic subclinical myocardial damage. Physical activity might lessen the association between obesity and subclinical myocardial damage, which could represent a mechanism by which physical activity reduces HF risk.

Alternate JournalJACC Heart Fail
PubMed ID28449797
PubMed Central IDPMC5412715
Grant ListK23 HL122447 / HL / NHLBI NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States