|Title||Midlife and Late-Life Vascular Risk Factors and White Matter Microstructural Integrity: The Atherosclerosis Risk in Communities Neurocognitive Study.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Power MC, Tingle JV, Reid RI, Huang J, Sharrett ARichey, Coresh JJ, Griswold M, Kantarci K, Jack CR, Knopman D, Gottesman RF|
|Secondary Authors||Mosley TH|
|Journal||J Am Heart Assoc|
|Date Published||2017 May 18|
|Keywords||Adult, Age Factors, Aged, Biomarkers, Blood Glucose, Blood Pressure, Cognition, Diffusion Tensor Imaging, Female, Glucose Metabolism Disorders, Humans, Hypertension, Leukoencephalopathies, Lipids, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Predictive Value of Tests, Prognosis, Risk Factors, Time Factors, United States, White Matter|
BACKGROUND: Diffusion tensor imaging measures of white matter (WM) microstructural integrity appear to provide earlier indication of WM injury than WM hyperintensities; however, risk factors for poor WM microstructural integrity have not been established. Our study quantifies the association between vascular risk factors in midlife and late life with measures of late-life WM microstructural integrity.
METHODS AND RESULTS: We used data from 1851 participants in ARIC (Atherosclerosis Risk in Communities Study) who completed 3-T magnetic resonance imaging, including diffusion tensor imaging, as part of the ARIC Neurocognitive Study (ARIC-NCS). We quantified the association among lipids, glucose, and blood pressure from the baseline ARIC visit (1987-1989, ages 44-65, midlife) and visit 5 of ARIC (2011-2013, ages 67-90, late life, concurrent with ARIC-NCS) with regional and overall WM mean diffusivity and fractional anisotropy obtained at ARIC visit 5 for ARIC participants. We also considered whether these associations were independent of or modified by WM hyperintensity volumes. We found that elevated blood pressure in midlife and late life and elevated glucose in midlife, but not late life, were associated with worse late-life WM microstructural integrity. These associations were independent of the degree of WM hyperintensity, and the association between glucose and WM microstructural integrity appeared stronger for those with the least WM hyperintensity. There was little support for an adverse association between lipids and WM microstructural integrity.
CONCLUSIONS: Hypertension in both midlife and late life and elevated glucose in midlife are related to worse WM microstructural integrity in late life.
|Alternate Journal||J Am Heart Assoc|
|PubMed Central ID||PMC5524102|
|Grant List||U01 HL096812 / HL / NHLBI NIH HHS / United States |
U01 HL096917 / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
K24 AG052573 / AG / NIA NIH HHS / United States