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Serum Levels of 1,5-Anhydroglucitol and Risk of Incident End-Stage Renal Disease.

TitleSerum Levels of 1,5-Anhydroglucitol and Risk of Incident End-Stage Renal Disease.
Publication TypeJournal Article
Year of Publication2017
AuthorsRebholz CM, Grams ME, Chen Y, Gross AL, Sang Y, Coresh JJ
Secondary AuthorsSelvin E
JournalAm J Epidemiol
Volume186
Issue8
Pagination952-960
Date Published2017 Oct 15
ISSN1476-6256
KeywordsBiomarkers, Blood Glucose, Cohort Studies, Deoxyglucose, Diabetes Complications, Female, Glomerular Filtration Rate, Glycated Hemoglobin A, Humans, Hyperglycemia, Incidence, Kidney Failure, Chronic, Male, Middle Aged, Regression Analysis, Risk Factors, Surveys and Questionnaires
Abstract

Glycemic excursions, independent of average glucose, have been implicated in the development of diabetic complications. It is unknown whether low levels of 1,5-anhydroglucitol (1,5-AG) are associated with advanced stages of kidney disease independent of kidney function and glycemia. In the Atherosclerosis Risk in Communities Study (n = 13,277 from 4 US communities), we used structural equation modeling to estimate the association between serum 1,5-AG levels and end-stage renal disease (ESRD) from baseline (1990-1992) through 2013 with adjustment for demographics, risk factors, a latent variable for glycemia (diabetes status, fasting glucose, glycated hemoglobin (HbA1c), fructosamine, glycated albumin), and a latent variable for kidney function (creatinine, cystatin C, ╬▓2-microglobulin). After adjusting for demographics, risk factors, and the latent variable for kidney function, the linear spline terms representing 1,5-AG levels

DOI10.1093/aje/kwx167
Alternate JournalAm J Epidemiol
PubMed ID28535187
PubMed Central IDPMC5860021
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
K01 DK107782 / DK / NIDDK NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
K08 DK092287 / DK / NIDDK NIH HHS / United States