Title | Serum Levels of 1,5-Anhydroglucitol and Risk of Incident End-Stage Renal Disease. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Rebholz CM, Grams ME, Chen Y, Gross AL, Sang Y, Coresh JJ |
Secondary Authors | Selvin E |
Journal | Am J Epidemiol |
Volume | 186 |
Issue | 8 |
Pagination | 952-960 |
Date Published | 2017 Oct 15 |
ISSN | 1476-6256 |
Keywords | Biomarkers, Blood Glucose, Cohort Studies, Deoxyglucose, Diabetes Complications, Female, Glomerular Filtration Rate, Glycated Hemoglobin A, Humans, Hyperglycemia, Incidence, Kidney Failure, Chronic, Male, Middle Aged, Regression Analysis, Risk Factors, Surveys and Questionnaires |
Abstract | Glycemic excursions, independent of average glucose, have been implicated in the development of diabetic complications. It is unknown whether low levels of 1,5-anhydroglucitol (1,5-AG) are associated with advanced stages of kidney disease independent of kidney function and glycemia. In the Atherosclerosis Risk in Communities Study (n = 13,277 from 4 US communities), we used structural equation modeling to estimate the association between serum 1,5-AG levels and end-stage renal disease (ESRD) from baseline (1990-1992) through 2013 with adjustment for demographics, risk factors, a latent variable for glycemia (diabetes status, fasting glucose, glycated hemoglobin (HbA1c), fructosamine, glycated albumin), and a latent variable for kidney function (creatinine, cystatin C, β2-microglobulin). After adjusting for demographics, risk factors, and the latent variable for kidney function, the linear spline terms representing 1,5-AG levels |
DOI | 10.1093/aje/kwx167 |
Alternate Journal | Am J Epidemiol |
PubMed ID | 28535187 |
PubMed Central ID | PMC5860021 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States R01 DK089174 / DK / NIDDK NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States K01 DK107782 / DK / NIDDK NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States K24 DK106414 / DK / NIDDK NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States K08 DK092287 / DK / NIDDK NIH HHS / United States |