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Brain function and structure and risk for incident diabetes: The Atherosclerosis Risk in Communities Study.

TitleBrain function and structure and risk for incident diabetes: The Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsBancks MP, Alonso A, Gottesman RF, Mosley TH, Selvin E
Secondary AuthorsPankow JS
JournalAlzheimers Dement
Volume13
Issue12
Pagination1345-1354
Date Published2017 Dec
ISSN1552-5279
KeywordsAged, Atherosclerosis, Blood Glucose, Brain, Cohort Studies, Diabetes Mellitus, Female, Humans, Incidence, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Residence Characteristics, Risk Factors, Severity of Illness Index
Abstract

INTRODUCTION: Diabetes is prospectively associated with cognitive decline. Whether lower cognitive function and worse brain structure are prospectively associated with incident diabetes is unclear.

METHODS: We analyzed data for 10,133 individuals with cognitive function testing (1990-1992) and 1212 individuals with brain magnetic resonance imaging (1993-1994) from the Atherosclerosis Risk in Communities cohort. We estimated hazard ratios for incident diabetes through 2014 after adjustment for traditional diabetes risk factors and cohort attrition.

RESULTS: Higher level of baseline cognitive function was associated with lower risk for diabetes (per 1 standard deviation, hazard ratio = 0.94; 95% confidence interval = 0.90, 0.98). This association did not persist after accounting for baseline glucose level, case ascertainment methods, and cohort attrition. No association was observed between any brain magnetic resonance imaging measure and incident diabetes.

DISCUSSION: This is one of the first studies to prospectively evaluate the association between both cognitive function and brain structure and the incidence of diabetes.

DOI10.1016/j.jalz.2017.04.006
Alternate JournalAlzheimers Dement
PubMed ID28624149
PubMed Central IDPMC5723547
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
K24 AG052573 / AG / NIA NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
N01 HC055018 / HC / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
T32 HL007779 / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
T32 HL069771 / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States