Title | Brain function and structure and risk for incident diabetes: The Atherosclerosis Risk in Communities Study. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Bancks MP, Alonso A, Gottesman RF, Mosley TH, Selvin E |
Secondary Authors | Pankow JS |
Journal | Alzheimers Dement |
Volume | 13 |
Issue | 12 |
Pagination | 1345-1354 |
Date Published | 2017 Dec |
ISSN | 1552-5279 |
Keywords | Aged, Atherosclerosis, Blood Glucose, Brain, Cohort Studies, Diabetes Mellitus, Female, Humans, Incidence, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Residence Characteristics, Risk Factors, Severity of Illness Index |
Abstract | INTRODUCTION: Diabetes is prospectively associated with cognitive decline. Whether lower cognitive function and worse brain structure are prospectively associated with incident diabetes is unclear. METHODS: We analyzed data for 10,133 individuals with cognitive function testing (1990-1992) and 1212 individuals with brain magnetic resonance imaging (1993-1994) from the Atherosclerosis Risk in Communities cohort. We estimated hazard ratios for incident diabetes through 2014 after adjustment for traditional diabetes risk factors and cohort attrition. RESULTS: Higher level of baseline cognitive function was associated with lower risk for diabetes (per 1 standard deviation, hazard ratio = 0.94; 95% confidence interval = 0.90, 0.98). This association did not persist after accounting for baseline glucose level, case ascertainment methods, and cohort attrition. No association was observed between any brain magnetic resonance imaging measure and incident diabetes. DISCUSSION: This is one of the first studies to prospectively evaluate the association between both cognitive function and brain structure and the incidence of diabetes. |
DOI | 10.1016/j.jalz.2017.04.006 |
Alternate Journal | Alzheimers Dement |
PubMed ID | 28624149 |
PubMed Central ID | PMC5723547 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States U01 HL096812 / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States R01 DK089174 / DK / NIDDK NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States K24 AG052573 / AG / NIA NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States N01 HC055018 / HC / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States T32 HL007779 / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States T32 HL069771 / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States K24 DK106414 / DK / NIDDK NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States R01 HL070825 / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States |