|Title||Ectopy on a Single 12-Lead ECG, Incident Cardiac Myopathy, and Death in the Community.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Nguyen KT, Vittinghoff E, Dewland TA, Dukes JW, Soliman EZ, Stein PK, Gottdiener JS, Alonso A, Chen LYee, Psaty BM, Heckbert SR|
|Secondary Authors||Marcus GM|
|Journal||J Am Heart Assoc|
|Date Published||2017 Aug 03|
|Keywords||Aged, Atrial Fibrillation, Atrial Premature Complexes, Cardiomyopathies, Electrocardiography, Female, Heart Failure, Humans, Incidence, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, United States, Ventricular Premature Complexes|
BACKGROUND: Atrial fibrillation and heart failure are 2 of the most common diseases, yet ready means to identify individuals at risk are lacking. The 12-lead ECG is one of the most accessible tests in medicine. Our objective was to determine whether a premature atrial contraction observed on a standard 12-lead ECG would predict atrial fibrillation and mortality and whether a premature ventricular contraction would predict heart failure and mortality.
METHODS AND RESULTS: We utilized the CHS (Cardiovascular Health) Study, which followed 5577 participants for a median of 12 years, as the primary cohort. The ARIC (Atherosclerosis Risk in Communities Study), the replication cohort, captured data from 15 792 participants over a median of 22 years. In the CHS, multivariable analyses revealed that a baseline 12-lead ECG premature atrial contraction predicted a 60% increased risk of atrial fibrillation (hazard ratio, 1.6; 95% CI, 1.3-2.0;
CONCLUSIONS: Based on a single standard ECG, a premature atrial contraction predicted incident atrial fibrillation and death and a premature ventricular contraction predicted incident heart failure and death, suggesting that this commonly used test may predict future disease.
|Alternate Journal||J Am Heart Assoc|
|PubMed Central ID||PMC5586444|
|Grant List||16EIA26410001 / AHA / American Heart Association-American Stroke Association / United States|