Title | Ectopy on a Single 12-Lead ECG, Incident Cardiac Myopathy, and Death in the Community. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Nguyen KT, Vittinghoff E, Dewland TA, Dukes JW, Soliman EZ, Stein PK, Gottdiener JS, Alonso A, Chen LYee, Psaty BM, Heckbert SR |
Secondary Authors | Marcus GM |
Journal | J Am Heart Assoc |
Volume | 6 |
Issue | 8 |
Date Published | 2017 Aug 03 |
ISSN | 2047-9980 |
Keywords | Aged, Atrial Fibrillation, Atrial Premature Complexes, Cardiomyopathies, Electrocardiography, Female, Heart Failure, Humans, Incidence, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, United States, Ventricular Premature Complexes |
Abstract | BACKGROUND: Atrial fibrillation and heart failure are 2 of the most common diseases, yet ready means to identify individuals at risk are lacking. The 12-lead ECG is one of the most accessible tests in medicine. Our objective was to determine whether a premature atrial contraction observed on a standard 12-lead ECG would predict atrial fibrillation and mortality and whether a premature ventricular contraction would predict heart failure and mortality. METHODS AND RESULTS: We utilized the CHS (Cardiovascular Health) Study, which followed 5577 participants for a median of 12 years, as the primary cohort. The ARIC (Atherosclerosis Risk in Communities Study), the replication cohort, captured data from 15 792 participants over a median of 22 years. In the CHS, multivariable analyses revealed that a baseline 12-lead ECG premature atrial contraction predicted a 60% increased risk of atrial fibrillation (hazard ratio, 1.6; 95% CI, 1.3-2.0; CONCLUSIONS: Based on a single standard ECG, a premature atrial contraction predicted incident atrial fibrillation and death and a premature ventricular contraction predicted incident heart failure and death, suggesting that this commonly used test may predict future disease. |
DOI | 10.1161/JAHA.117.006028 |
Alternate Journal | J Am Heart Assoc |
PubMed ID | 28775064 |
PubMed Central ID | PMC5586444 |
Grant List | 16EIA26410001 / AHA / American Heart Association-American Stroke Association / United States |