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Community burden and prognostic impact of reduced kidney function among patients hospitalized with acute decompensated heart failure: The Atherosclerosis Risk in Communities (ARIC) Study Community Surveillance.

TitleCommunity burden and prognostic impact of reduced kidney function among patients hospitalized with acute decompensated heart failure: The Atherosclerosis Risk in Communities (ARIC) Study Community Surveillance.
Publication TypeJournal Article
Year of Publication2017
AuthorsMatsushita K, Kwak L, Hyun N, Bessel M, Agarwal SK, Loehr LR, Ni H, Chang PP, Coresh JJ, Wruck LM
Secondary AuthorsRosamond WD
JournalPLoS One
Volume12
Issue8
Paginatione0181373
Date Published2017
ISSN1932-6203
KeywordsAged, Atherosclerosis, Blood Urea Nitrogen, Cost of Illness, Creatinine, Female, Glomerular Filtration Rate, Heart Failure, Humans, Kidney, Kidney Diseases, Kidney Function Tests, Male, Prognosis, Public Health Surveillance, Risk Assessment, Risk Factors
Abstract

BACKGROUND: Kidney dysfunction is prevalent and impacts prognosis in patients with acute decompensated heart failure (ADHF). However, most previous reports were from a single hospital, limiting their generalizability. Also, contemporary data using new equation for estimated glomerular filtration rate (eGFR) are needed.

METHODS AND RESULTS: We analyzed data from the ARIC Community Surveillance for ADHF conducted for residents aged ≥55 years in four US communities between 2005-2011. All ADHF cases (n = 5, 391) were adjudicated and weighted to represent those communities (24,932 weighted cases). The association of kidney function (creatinine-based eGFR by the CKD-EPI equation and blood urea nitrogen [BUN]) during hospitalization with 1-year mortality was assessed using logistic regression. Based on worst and last serum creatinine, there were 82.5% and 70.6% with reduced eGFR (

CONCLUSIONS: Severely reduced eGFR (

DOI10.1371/journal.pone.0181373
Alternate JournalPLoS One
PubMed ID28793319
PubMed Central IDPMC5549913