| Title | Community burden and prognostic impact of reduced kidney function among patients hospitalized with acute decompensated heart failure: The Atherosclerosis Risk in Communities (ARIC) Study Community Surveillance. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Matsushita K, Kwak L, Hyun N, Bessel M, Agarwal SK, Loehr LR, Ni H, Chang PP, Coresh JJ, Wruck LM |
| Secondary Authors | Rosamond WD |
| Journal | PLoS One |
| Volume | 12 |
| Issue | 8 |
| Pagination | e0181373 |
| Date Published | 2017 |
| ISSN | 1932-6203 |
| Keywords | Aged, Atherosclerosis, Blood Urea Nitrogen, Cost of Illness, Creatinine, Female, Glomerular Filtration Rate, Heart Failure, Humans, Kidney, Kidney Diseases, Kidney Function Tests, Male, Prognosis, Public Health Surveillance, Risk Assessment, Risk Factors |
| Abstract | BACKGROUND: Kidney dysfunction is prevalent and impacts prognosis in patients with acute decompensated heart failure (ADHF). However, most previous reports were from a single hospital, limiting their generalizability. Also, contemporary data using new equation for estimated glomerular filtration rate (eGFR) are needed. METHODS AND RESULTS: We analyzed data from the ARIC Community Surveillance for ADHF conducted for residents aged ≥55 years in four US communities between 2005-2011. All ADHF cases (n = 5, 391) were adjudicated and weighted to represent those communities (24,932 weighted cases). The association of kidney function (creatinine-based eGFR by the CKD-EPI equation and blood urea nitrogen [BUN]) during hospitalization with 1-year mortality was assessed using logistic regression. Based on worst and last serum creatinine, there were 82.5% and 70.6% with reduced eGFR ( CONCLUSIONS: Severely reduced eGFR ( |
| DOI | 10.1371/journal.pone.0181373 |
| Alternate Journal | PLoS One |
| PubMed ID | 28793319 |
| PubMed Central ID | PMC5549913 |