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The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study.

TitleThe Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsHess PL, Al-Khalidi HR, Friedman DJ, Mulder H, Kucharska-Newton AMaria, Rosamond WD, Lopes RD, Gersh BJ, Mark DB, Curtis LH, Post WS, Prineas RJ, Sotoodehnia N
Secondary AuthorsAl-Khatib SM
JournalJ Am Heart Assoc
Volume6
Issue8
Date Published2017 Aug 23
ISSN2047-9980
KeywordsAtherosclerosis, Biomarkers, Blood Glucose, Blood Pressure, Death, Sudden, Cardiac, Dyslipidemias, Female, Glucose Metabolism Disorders, Humans, Hypertension, Incidence, Lipoproteins, LDL, Male, Metabolic Syndrome, Middle Aged, Prevalence, Prospective Studies, Risk Assessment, Risk Factors, Time Factors, United States
Abstract

BACKGROUND: Prior studies have demonstrated a link between the metabolic syndrome and increased risk of cardiovascular mortality. Whether the metabolic syndrome is associated with sudden cardiac death is uncertain.

METHODS AND RESULTS: We characterized the relationship between sudden cardiac death and metabolic syndrome status among participants of the ARIC (Atherosclerosis Risk in Communities) Study (1987-2012) free of prevalent coronary heart disease or heart failure. Among 13 168 participants, 357 (2.7%) sudden cardiac deaths occurred during a median follow-up of 23.6 years. Participants with the metabolic syndrome (n=4444) had a higher cumulative incidence of sudden cardiac death than those without it (n=8724) (4.1% versus 2.3%,

CONCLUSIONS: We observed that the metabolic syndrome was associated with a significantly increased risk of sudden cardiac death irrespective of sex or race. The risk of sudden cardiac death was proportional to the number of metabolic syndrome components.
DOI10.1161/JAHA.117.006103
Alternate JournalJ Am Heart Assoc
PubMed ID28835363
PubMed Central IDPMC5586451
Grant ListT32 HL069749 / HL / NHLBI NIH HHS / United States