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Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study.

TitleMetabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2017
AuthorsBressler J, Yu B, Mosley TH, Knopman DS, Gottesman RF, Alonso A, Sharrett ARichey, Wruck LM
Secondary AuthorsBoerwinkle E
JournalTransl Psychiatry
Volume7
Issue7
Paginatione1173
Date Published2017 07 18
ISSN2158-3188
KeywordsAfrican Americans, African Continental Ancestry Group, Atherosclerosis, Cognition, European Continental Ancestry Group, Female, Humans, Longitudinal Studies, Male, Metabolomics, Middle Aged, Neuropsychological Tests, Prospective Studies, Risk Factors
Abstract

Clinical studies have shown alterations in metabolic profiles when patients with mild cognitive impairment and Alzheimer's disease dementia were compared to cognitively normal subjects. Associations between 204 serum metabolites measured at baseline (1987-1989) and cognitive change were investigated in 1035 middle-aged community-dwelling African American participants in the biracial Atherosclerosis Risk in Communities (ARIC) Study. Cognition was evaluated using the Delayed Word Recall Test (DWRT; verbal memory), the Digit Symbol Substitution Test (DSST; processing speed) and the Word Fluency Test (WFT; verbal fluency) at visits 2 (1990-1992) and 4 (1996-1998). In addition, Cox regression was used to analyze the metabolites as predictors of incident hospitalized dementia between baseline and 2011. There were 141 cases among 1534 participants over a median 17.1-year follow-up period. After adjustment for established risk factors, one standard deviation increase in N-acetyl-1-methylhistidine was significantly associated with greater 6-year change in DWRT scores (β=-0.66 words; P=3.65 × 10). Two metabolites (one unnamed and a long-chain omega-6 polyunsaturated fatty acid found in vegetable oils (docosapentaenoate (DPA, 22:5 n-6)) were significantly associated with less decline on the DSST (DPA: β=1.25 digit-symbol pairs, P=9.47 × 10). Two unnamed compounds and three sex steroid hormones were associated with an increased risk of dementia (all P

DOI10.1038/tp.2017.118
Alternate JournalTransl Psychiatry
PubMed ID28934192
PubMed Central IDPMC5538110
Grant ListHHSN268201100008C / HL / NHLBI NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States