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Kidney Disease Measures and Left Ventricular Structure and Function: The Atherosclerosis Risk in Communities Study.

TitleKidney Disease Measures and Left Ventricular Structure and Function: The Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsMatsushita K, Kwak L, Sang Y, Ballew SH, Skali H, Shah AM, Coresh JJ
Secondary AuthorsSolomon S
JournalJ Am Heart Assoc
Volume6
Issue9
Date Published2017 Sep 22
ISSN2047-9980
KeywordsAged, Aged, 80 and over, Albuminuria, Biomarkers, Creatinine, Echocardiography, Doppler, Female, Glomerular Filtration Rate, Heart Failure, Humans, Kidney, Male, Renal Insufficiency, Chronic, Risk Factors, United States, Ventricular Dysfunction, Left, Ventricular Function, Left, Ventricular Remodeling
Abstract

BACKGROUND: Heart failure is one of the most important complications of chronic kidney disease (CKD). However, few studies comprehensively investigated left ventricular (LV) structure and function in relation to 2 key CKD measures, estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR).

METHODS AND RESULTS: Among 4175 ARIC (Atherosclerosis Risk in Communities) participants (aged 66-90 years during 2011-2013), we quantified the association of eGFR and ACR with echocardiogram parameters of LV mass, size, systolic function, and diastolic function. Adjusting for demographic variables, both CKD measures were significantly associated with most echocardiogram parameters. Additionally accounting for other potential confounders, we observed significantly higher LV mass index according to reduced eGFR (82.3 [95% confidence interval (CI), 77.6-87.0] g/m for eGFR

CONCLUSIONS: LV mass was related to both CKD measures, whereas LV size and function were robustly associated with albuminuria. These results have implications for pathophysiological processes behind cardiorenal syndrome and targeted cardiac assessment in patients with CKD.

DOI10.1161/JAHA.117.006259
Alternate JournalJ Am Heart Assoc
PubMed ID28939714
PubMed Central IDPMC5634280