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Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent.

TitleGenome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent.
Publication TypeJournal Article
Year of Publication2018
AuthorsSmith CE, Follis JL, Dashti HS, Tanaka T, Graff M, Fretts AM, Kilpeläinen TO, Wojczynski MK, Richardson K, Nalls MA, Schulz C-A, Liu Y, Frazier-Wood AC, van Eekelen E, Wang C, de Vries PS, Mikkilä V, Rohde R, Psaty BM, Hansen T, Feitosa MF, Lai C-Q, Houston DK, Ferruci L, Ericson U, Wang Z, de Mutsert R, Oddy WH, de Jonge EAL, Seppälä I, Justice AE, Lemaitre RN, Sørensen TIA, Province MA, Parnell LD, Garcia ME, Bandinelli S, Orho-Melander M, Rich SS, Rosendaal FR, Pennell CE, de Jong JCKiefte-, Kähönen M, Young KL, Pedersen O, Aslibekyan S, Rotter JI, Mook-Kanamori DO, Zillikens CM, Raitakari OT, North KE, Overvad K, Arnett DK, Hofman A, Lehtimäki T, Tjønneland A, Uitterlinden AG, Rivadeneira F, Franco OH, J German B, Siscovick DS, L Cupples A
Secondary AuthorsOrdovas JM
JournalMol Nutr Food Res
Volume62
Issue3
Date Published2018 02
ISSN1613-4133
KeywordsActins, Adult, Aged, Body Mass Index, Cohort Studies, Cross-Sectional Studies, Dairy Products, European Continental Ancestry Group, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Myosin-Light-Chain Phosphatase, Polymorphism, Single Nucleotide
Abstract

SCOPE: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption.

METHODS AND RESULTS: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction

CONCLUSION: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.

DOI10.1002/mnfr.201700347
Alternate JournalMol Nutr Food Res
PubMed ID28941034
PubMed Central IDPMC5803424
Grant ListR01 HL091357 / HL / NHLBI NIH HHS / United States
U01 HL130114 / HL / NHLBI NIH HHS / United States
P30 DK056341 / DK / NIDDK NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
R01 DK089256 / DK / NIDDK NIH HHS / United States
R01 HL117078 / HL / NHLBI NIH HHS / United States
UL1 TR001881 / TR / NCATS NIH HHS / United States
K08 HL112845 / HL / NHLBI NIH HHS / United States
KL2 TR001109 / TR / NCATS NIH HHS / United States
R00 HL130580 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
U01 HL072524 / HL / NHLBI NIH HHS / United States