| Title | is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Rannikmae K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernandez-Cadenas I, Jimenez-Conde J, Lindgren A, Montaner J, O'Donnell M, Paré G, Radmanesh F, Rost NS, Slowik A, Söderholm M, Traylor M, Pulit SL, Seshadri S, Worrall BB, Woo D, Markus HS, Mitchell BD, Dichgans M, Rosand J |
| Secondary Authors | Sudlow CLM |
| Corporate Authors | Stroke Genetics Network(SiGN), METASTROKE Collaboration, and International Stroke Genetics Consortium(ISGC) |
| Journal | Neurology |
| Volume | 89 |
| Issue | 17 |
| Pagination | 1829-1839 |
| Date Published | 2017 Oct 24 |
| ISSN | 1526-632X |
| Keywords | Cerebral Hemorrhage, Collagen Type IV, Europe, Genetic Association Studies, Humans, Polymorphism, Single Nucleotide, Stroke, Lacunar |
| Abstract | OBJECTIVE: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD. METHODS: We meta-analyzed genotype data from individuals of European ancestry to determine associations of common single nucleotide polymorphisms (SNPs) in 6 familial cerebral SVD genes (, , , , , and ) with intracerebral hemorrhage (ICH) (deep, lobar, all; 1,878 cases, 2,830 controls) and ischemic stroke (IS) (lacunar, cardioembolic, large vessel disease, all; 19,569 cases, 37,853 controls). We applied data quality filters and set statistical significance thresholds accounting for linkage disequilibrium and multiple testing. RESULTS: A locus in was associated (significance threshold CONCLUSIONS: These results provide evidence of shared genetic determinants and suggest common pathophysiologic mechanisms of distinct ischemic and hemorrhagic cerebral SVD stroke phenotypes, offering new insights into the causal mechanisms of cerebral SVD. |
| DOI | 10.1212/WNL.0000000000004560 |
| Alternate Journal | Neurology |
| PubMed ID | 28954878 |
| PubMed Central ID | PMC5664302 |
| Grant List | U01 AG009740 / AG / NIA NIH HHS / United States UL1 TR001863 / TR / NCATS NIH HHS / United States K23 NS100816 / NS / NINDS NIH HHS / United States KL2 TR001429 / TR / NCATS NIH HHS / United States R01 HL088521 / HL / NHLBI NIH HHS / United States U01 NS036695 / NS / NINDS NIH HHS / United States |