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Heart rate variability and lifetime risk of cardiovascular disease: the Atherosclerosis Risk in Communities Study.

TitleHeart rate variability and lifetime risk of cardiovascular disease: the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsKubota Y, Chen LYee, Whitsel EA
Secondary AuthorsFolsom AR
JournalAnn Epidemiol
Volume27
Issue10
Pagination619-625.e2
Date Published2017 10
ISSN1873-2585
KeywordsAged, Atherosclerosis, Cardiovascular Diseases, Female, Heart Failure, Heart Rate, Humans, Longitudinal Studies, Male, Middle Aged, Population Surveillance, Prospective Studies, Risk Assessment, Stroke
Abstract

PURPOSE: The purpose of this study was to estimate the heart rate variability (HRV)-related lifetime cardiovascular disease (CVD) risk.

METHODS: We followed 9744 participants without baseline CVD and used a life-table approach to estimate lifetime CVD risk (coronary heart disease, heart failure, and stroke) from 45 through 85 years according to several HRV measures (the SD of RR intervals [SD], the root mean square of successive differences of successive RR intervals, the mean of all normal RR intervals [mean], low-frequency [LF] and high-frequency [HF] power, and the LF/HF ratio).

RESULTS: During 192,110 person-years of follow-up, we documented 2856 CVD events. Cox regression analyses with the false discovery rate method correction showed independent associations of SD, mean, LF, and LF/HF in women with CVD. Lifetime CVD risks in the lowest compared with the highest tertile were significantly increased in men for LF/HF (51.3% [95% confidence interval, 47.3-54.7] vs. 43.9% [40.1-47.2]), and in women for SD (39.4% [36.0-43.0] vs. 29.9% [26.3-33.0]), mean (39.3% [35.7-42.7] vs. 28.9% [25.7-31.7]), LF (39.4% [35.9-43.0] vs. 30.0% [26.2-33.2]), and LF/HF (37.6% [33.9-40.9] vs. 30.0% [26.8-32.7]).

CONCLUSIONS: Greater HRV was modestly associated with lower lifetime CVD risk.

DOI10.1016/j.annepidem.2017.08.024
Alternate JournalAnn Epidemiol
PubMed ID29033120
PubMed Central IDPMC5821272
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States