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Prospective study of lung function and abdominal aortic aneurysm risk: The Atherosclerosis Risk in Communities study.

TitleProspective study of lung function and abdominal aortic aneurysm risk: The Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2018
AuthorsKubota Y, Folsom AR, Matsushita K, Couper DJ
Secondary AuthorsTang W
JournalAtherosclerosis
Volume268
Pagination225-230
Date Published2018 01
ISSN1879-1484
KeywordsAortic Aneurysm, Abdominal, Female, Forced Expiratory Volume, Humans, Incidence, Lung, Male, Middle Aged, Prognosis, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Risk Assessment, Risk Factors, Spirometry, Time Factors, United States, Vital Capacity
Abstract

BACKGROUND AND AIMS: No prospective study has investigated whether individuals with respiratory impairments, including chronic obstructive pulmonary disease (COPD) and restrictive lung disease (RLD), are at increased risk of abdominal aortic aneurysm (AAA). We aimed to prospectively investigate whether those respiratory impairments are associated with increased AAA risk.

METHODS: In 1987-1989, the Atherosclerosis Risk in Communities (ARIC) study followed 14,269 participants aged 45-64 years, without a history of AAA surgery, through 2011. Participants were classified into four groups, "COPD" [forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC)

RESULTS: During the 284,969 person-years of follow-up, 534 incident AAA events were documented. In an age, sex, and race-adjusted proportional hazards model, individuals with respiratory impairments had a significantly higher risk of AAA than the normal reference group. After adjustment for AAA risk factors, including smoking status and pack-years of smoking, AAA risk was no longer significant in the respiratory symptoms with normal spirometry group [HR (95% CI), 1.25 (0.98-1.60)], but was still increased in the other two groups [RLD: 1.45 (1.04-2.02) and COPD: 1.66 (1.34-2.05)]. Moreover, continuous measures of FEV1/FVC, FEV1 and FVC were associated inversely with risk of AAA.

CONCLUSIONS: In the prospective population-based cohort study, obstructive and restrictive spirometric patterns were associated with increased risk of AAA independent of smoking, suggesting that COPD and RLD may increase the risk of AAA.

DOI10.1016/j.atherosclerosis.2017.10.013
Alternate JournalAtherosclerosis
PubMed ID29079449
PubMed Central IDPMC5785925
Grant ListHHSN268201100008C / HL / NHLBI NIH HHS / United States
R01 HL103695 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201000010C / HL / NHLBI NIH HHS / United States
HHSN268201000011C / HL / NHLBI NIH HHS / United States
HHSN268201000012C / HL / NHLBI NIH HHS / United States