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Epigenome-wide association studies identify DNA methylation associated with kidney function.

TitleEpigenome-wide association studies identify DNA methylation associated with kidney function.
Publication TypeJournal Article
Year of Publication2017
AuthorsChu AY, Tin A, Schlosser P, Ko Y-A, Qiu C, Yao C, Joehanes R, Grams ME, Liang L, Gluck CA, Liu C, Coresh JJ, Hwang S-J, Levy D, Boerwinkle E, Pankow JS, Yang Q, Fornage M, Fox CS, Susztak K
Secondary AuthorsKöttgen A
JournalNat Commun
Volume8
Issue1
Pagination1286
Date Published2017 11 03
ISSN2041-1723
KeywordsAged, Binding Sites, CCAAT-Enhancer-Binding Protein-beta, CpG Islands, Disease Progression, DNA Methylation, E1A-Associated p300 Protein, Epigenesis, Genetic, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Glomerular Filtration Rate, Humans, Kidney, Male, Middle Aged, Prospective Studies, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Renal Insufficiency, Chronic, Trans-Activators, Transcription Factors
Abstract

Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart Study participants to identify epigenetic signatures of kidney function. Of 19 CpG sites significantly associated (P 

DOI10.1038/s41467-017-01297-7
Alternate JournalNat Commun
PubMed ID29097680
PubMed Central IDPMC5668367
Grant ListHHSN268201100009I / HL / NHLBI NIH HHS / United States
F32 DK112635 / DK / NIDDK NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R01 DK087635 / DK / NIDDK NIH HHS / United States
P30 DK046200 / DK / NIDDK NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
R01 DK076077 / DK / NIDDK NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
RC2 HL102419 / HL / NHLBI NIH HHS / United States
DP3 DK108220 / DK / NIDDK NIH HHS / United States
R21 DK112087 / DK / NIDDK NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States