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GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

TitleGWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.
Publication TypeJournal Article
Year of Publication2017
AuthorsPirastu N, Joshi PK, de Vries PS, Cornelis MC, McKeigue PM, Keum NN, Franceschini N, Colombo M, Giovannucci EL, Spiliopoulou A, Franke L, North KE, Kraft P, Morrison AC, Esko T
Secondary AuthorsWilson JF
JournalNat Commun
Volume8
Issue1
Pagination1584
Date Published2017 11 17
ISSN2041-1723
KeywordsAlopecia, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide, Prospective Studies, Risk, Surveys and Questionnaires
Abstract

Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence of ~50% by the age of 50; however, the known genes explain little of the heritability. Here, we present the results of a genome-wide association study including more than 70,000 men, identifying 71 independently replicated loci, of which 30 are novel. These loci explain 38% of the risk, suggesting that MPB is less genetically complex than other complex traits. We show that many of these loci contain genes thatĀ are relevant to the pathology and highlight pathways and functions underlying baldness. Finally, despite only showing genome-wide genetic correlation with height, pathway-specific genetic correlations are significant for traits including lifespan and cancer. Our study not only greatly increases the number of MPB loci, illuminating the genetic architecture, but also provides a new approach to disentangling the shared biological pathways underlying complex diseases.

DOI10.1038/s41467-017-01490-8
Alternate JournalNat Commun
PubMed ID29146897
PubMed Central IDPMC5691155
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
R01 CA059045 / CA / NCI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
R01 DK058845 / DK / NIDDK NIH HHS / United States
U01 HG004728 / HG / NHGRI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
P01 DK070756 / DK / NIDDK NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
U01 CA137088 / CA / NCI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
UM1 CA167552 / CA / NCI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
R01 HL035464 / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
U01 HG004399 / HG / NHGRI NIH HHS / United States
/ / Medical Research Council / United Kingdom