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Weight History and Subclinical Myocardial Damage.

TitleWeight History and Subclinical Myocardial Damage.
Publication TypeJournal Article
Year of Publication2018
AuthorsNdumele CE, Cobb L, Lazo M, Bello NA, Shah A, Nambi V, Blumenthal RS, Gerstenblith G, Solomon SD, Ballantyne CM, Selvin E
Secondary AuthorsCoresh JJ
JournalClin Chem
Volume64
Issue1
Pagination201-209
Date Published2018 01
ISSN1530-8561
KeywordsAdult, Atherosclerosis, Body Mass Index, Female, Heart Failure, Humans, Male, Middle Aged, Myocardium, Obesity, Troponin T
Abstract

BACKGROUND: Excess weight is associated with subclinical myocardial damage, as reflected by high-sensitivity cardiac troponin T (hs-cTnT) concentrations, which portends high heart failure risk. However, the association between weight history and myocardial damage is unknown.

METHODS: We evaluated 9062 Atherosclerosis Risk in Communities (ARIC) visit 4 (1996-1999) participants with a body mass index (BMI) ≥ 18.5 kg/m and no previous cardiovascular disease. We cross-tabulated visit 4 ("current") BMI categories of normal weight, overweight, and obese with those at visit 1 (1987-1989) and with BMI categories calculated from self-reported weight at age 25 years. Duration of obesity was calculated in years. A cumulative weight measure of "excess BMI-years" was also calculated [product of mean BMI (centered at 25 kg/m) over all ARIC time points × follow-up duration]. We used logistic regression to estimate associations of weight history metrics with increased hs-cTnT (≥14 ng/L) at visit 4.

RESULTS: Overall, 623 individuals (7%) had increased hs-cTnT at visit 4. Within each current BMI category, previous excess weight was associated with increased hs-cTnT, with the strongest associations for those with past and current obesity [odds ratio (OR), 3.85; 95% CI, 2.51-5.90 for obesity at age 25 years and visit 4]. Each 10-year longer obesity duration was associated with increased hs-cTnT (OR, 1.26; 95% CI, 1.17-1.35). Each 100 higher excess BMI-years was also progressively associated with increased hs-cTnT (OR, 1.21; 95% CI, 1.14-1.27).

CONCLUSIONS: Previous obesity and greater cumulative weight from young adulthood increase the likelihood of myocardial damage, indicating long-term toxic effects of adiposity on the myocardium and the need for weight maintenance strategies targeting the entire life span.

DOI10.1373/clinchem.2017.282798
Alternate JournalClin Chem
PubMed ID29158254
PubMed Central IDPMC6219376
Grant ListK23 HL122447 / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
KL2 TR001874 / TR / NCATS NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
HHSN268201000021C / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
UL1 TR001873 / TR / NCATS NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States