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Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies.

TitleDairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies.
Publication TypeJournal Article
Year of Publication2018
Corporate AuthorsMendelian Randomization of Dairy Consumption Working Group
JournalClin Chem
Volume64
Issue1
Pagination183-191
Date Published2018 01
ISSN1530-8561
KeywordsAdult, Body Mass Index, Body Weight, Cross-Sectional Studies, Dairy Products, Genotype, Humans, Mendelian Randomization Analysis, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Prospective Studies
Abstract

BACKGROUND: Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined.

METHODS: We performed Mendelian randomization (MR) analysis using an established dairy intake-associated genetic polymorphism located upstream of the lactase gene (-13910 C/T, rs4988235) as an instrumental variable (IV). Linear regression models were fitted to analyze associations between () dairy intake and BMI, () rs4988235 and dairy intake, and () rs4988235 and BMI in each study. The causal effect of dairy intake on BMI was quantified by IV estimators among 184802 participants from 25 studies.

RESULTS: Higher dairy intake was associated with higher BMI (β = 0.03 kg/m per serving/day; 95% CI, 0.00-0.06; = 0.04), whereas the genotype with 1 or 2 T allele was significantly associated with 0.20 (95% CI, 0.14-0.25) serving/day higher dairy intake ( = 3.15 × 10) and 0.12 (95% CI, 0.06-0.17) kg/m higher BMI ( = 2.11 × 10). MR analysis showed that the genetically determined higher dairy intake was significantly associated with higher BMI (β = 0.60 kg/m per serving/day; 95% CI, 0.27-0.92; = 3.0 × 10).

CONCLUSIONS: The present study provides strong evidence to support a causal effect of higher dairy intake on increased BMI among adults.

DOI10.1373/clinchem.2017.280701
Alternate JournalClin Chem
PubMed ID29187356
PubMed Central IDPMC5837824
Grant ListR01 HL091357 / HL / NHLBI NIH HHS / United States
R01 DK115679 / DK / NIDDK NIH HHS / United States
U01 HL130114 / HL / NHLBI NIH HHS / United States
R01 DK091718 / DK / NIDDK NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
U01 HL072524 / HL / NHLBI NIH HHS / United States
R21 HL126024 / HL / NHLBI NIH HHS / United States
R01 DK100383 / DK / NIDDK NIH HHS / United States
R01 DK089256 / DK / NIDDK NIH HHS / United States
U01 HG004399 / HG / NHGRI NIH HHS / United States
U01 CA137088 / CA / NCI NIH HHS / United States
U54 CA155626 / CA / NCI NIH HHS / United States
U01 HG004728 / HG / NHGRI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
N01HC95159 / HL / NHLBI NIH HHS / United States
N01HC95160 / HL / NHLBI NIH HHS / United States
N01HC95161 / HL / NHLBI NIH HHS / United States
N01HC95162 / HL / NHLBI NIH HHS / United States
N01HC95163 / HL / NHLBI NIH HHS / United States
N01HC95164 / HL / NHLBI NIH HHS / United States
N01HC95165 / HL / NHLBI NIH HHS / United States
N01HC95166 / HL / NHLBI NIH HHS / United States
N01HC95167 / HL / NHLBI NIH HHS / United States
N01HC95168 / HL / NHLBI NIH HHS / United States
N01HC95169 / HL / NHLBI NIH HHS / United States
UL1 TR000040 / TR / NCATS NIH HHS / United States
UL1 TR001079 / TR / NCATS NIH HHS / United States
HHSN268201200036C / HL / NHLBI NIH HHS / United States
HHSN268200800007C / HL / NHLBI NIH HHS / United States
N01HC55222 / HL / NHLBI NIH HHS / United States
N01HC85079 / HL / NHLBI NIH HHS / United States
N01HC85080 / HL / NHLBI NIH HHS / United States
N01HC85081 / HL / NHLBI NIH HHS / United States
N01HC85082 / HL / NHLBI NIH HHS / United States
N01HC85083 / HL / NHLBI NIH HHS / United States
N01HC85086 / HL / NHLBI NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
R01 HL087652 / HL / NHLBI NIH HHS / United States
R01 HL103612 / HL / NHLBI NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
UL1 TR001881 / TR / NCATS NIH HHS / United States
P01 AG023394 / AG / NIA NIH HHS / United States
P50 HL105185 / HL / NHLBI NIH HHS / United States
MOP-82893 / / CIHR / Canada
K08 HL112845 / HL / NHLBI NIH HHS / United States