Title | Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Corporate Authors | Mendelian Randomization of Dairy Consumption Working Group |
Journal | Clin Chem |
Volume | 64 |
Issue | 1 |
Pagination | 183-191 |
Date Published | 2018 01 |
ISSN | 1530-8561 |
Keywords | Adult, Body Mass Index, Body Weight, Cross-Sectional Studies, Dairy Products, Genotype, Humans, Mendelian Randomization Analysis, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Prospective Studies |
Abstract | BACKGROUND: Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined. METHODS: We performed Mendelian randomization (MR) analysis using an established dairy intake-associated genetic polymorphism located upstream of the lactase gene (-13910 C/T, rs4988235) as an instrumental variable (IV). Linear regression models were fitted to analyze associations between () dairy intake and BMI, () rs4988235 and dairy intake, and () rs4988235 and BMI in each study. The causal effect of dairy intake on BMI was quantified by IV estimators among 184802 participants from 25 studies. RESULTS: Higher dairy intake was associated with higher BMI (β = 0.03 kg/m per serving/day; 95% CI, 0.00-0.06; = 0.04), whereas the genotype with 1 or 2 T allele was significantly associated with 0.20 (95% CI, 0.14-0.25) serving/day higher dairy intake ( = 3.15 × 10) and 0.12 (95% CI, 0.06-0.17) kg/m higher BMI ( = 2.11 × 10). MR analysis showed that the genetically determined higher dairy intake was significantly associated with higher BMI (β = 0.60 kg/m per serving/day; 95% CI, 0.27-0.92; = 3.0 × 10). CONCLUSIONS: The present study provides strong evidence to support a causal effect of higher dairy intake on increased BMI among adults. |
DOI | 10.1373/clinchem.2017.280701 |
Alternate Journal | Clin Chem |
PubMed ID | 29187356 |
PubMed Central ID | PMC5837824 |
Grant List | R01 HL091357 / HL / NHLBI NIH HHS / United States R01 DK115679 / DK / NIDDK NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States R01 DK091718 / DK / NIDDK NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States U01 HL072524 / HL / NHLBI NIH HHS / United States R21 HL126024 / HL / NHLBI NIH HHS / United States R01 DK100383 / DK / NIDDK NIH HHS / United States R01 DK089256 / DK / NIDDK NIH HHS / United States U01 HG004399 / HG / NHGRI NIH HHS / United States U01 CA137088 / CA / NCI NIH HHS / United States U54 CA155626 / CA / NCI NIH HHS / United States U01 HG004728 / HG / NHGRI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States HHSN268201100012C / HL / NHLBI NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States N01HC95159 / HL / NHLBI NIH HHS / United States N01HC95160 / HL / NHLBI NIH HHS / United States N01HC95161 / HL / NHLBI NIH HHS / United States N01HC95162 / HL / NHLBI NIH HHS / United States N01HC95163 / HL / NHLBI NIH HHS / United States N01HC95164 / HL / NHLBI NIH HHS / United States N01HC95165 / HL / NHLBI NIH HHS / United States N01HC95166 / HL / NHLBI NIH HHS / United States N01HC95167 / HL / NHLBI NIH HHS / United States N01HC95168 / HL / NHLBI NIH HHS / United States N01HC95169 / HL / NHLBI NIH HHS / United States UL1 TR000040 / TR / NCATS NIH HHS / United States UL1 TR001079 / TR / NCATS NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States R01 HL087652 / HL / NHLBI NIH HHS / United States R01 HL103612 / HL / NHLBI NIH HHS / United States R01 HL120393 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States UL1 TR001881 / TR / NCATS NIH HHS / United States P01 AG023394 / AG / NIA NIH HHS / United States P50 HL105185 / HL / NHLBI NIH HHS / United States MOP-82893 / / CIHR / Canada K08 HL112845 / HL / NHLBI NIH HHS / United States |