|Title||Associations of Lipoprotein(a) Levels With Incident Atrial Fibrillation and Ischemic Stroke: The ARIC (Atherosclerosis Risk in Communities) Study.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Aronis KN, Zhao D, Hoogeveen RC, Alonso A, Ballantyne CM, Guallar E, Jones SR, Martin SS, Nazarian S, Steffen BT, Virani SS|
|Secondary Authors||Michos ED|
|Journal||J Am Heart Assoc|
|Date Published||2017 Dec 15|
|Keywords||Atherosclerosis, Atrial Fibrillation, Biomarkers, Brain Ischemia, Coronary Artery Disease, Electrocardiography, Female, Follow-Up Studies, Humans, Incidence, Lipoprotein(a), Male, Middle Aged, Prospective Studies, Risk Assessment, Risk Factors, Survival Rate, Time Factors, United States|
BACKGROUND: Lipoprotein(a) (Lp[a]) is proatherosclerotic and prothrombotic, causally related to coronary disease, and associated with other cardiovascular diseases. The association of Lp(a) with incident atrial fibrillation (AF) and with ischemic stroke among individuals with AF remains to be elucidated.
METHODS AND RESULTS: In the community-based ARIC (Atherosclerosis Risk in Communities) study cohort, Lp(a) levels were measured by a Denka Seiken assay at visit 4 (1996-1998). We used multivariable-adjusted Cox models to compare AF and ischemic stroke risk across Lp(a) levels. First, we evaluated incident AF in 9908 participants free of AF at baseline. AF was ascertained by electrocardiography at study visits, hospital () codes, and death certificates. We then evaluated incident ischemic stroke in 10 127 participants free of stroke at baseline. Stroke was identified by annual phone calls, hospital codes, and death certificates. The baseline age was 62.7±5.6 years. Median Lp(a) levels were 13.3 mg/dL (interquartile range, 5.2-39.7 mg/dL). Median follow-up was 13.9 and 15.8 years for AF and stroke, respectively. Lp(a) was not associated with incident AF (hazard ratio, 0.98; 95% confidence interval, 0.82-1.17), comparing those with Lp(a) ≥50 with those with Lp(a)
CONCLUSIONS: High Lp(a) levels were not associated with incident AF. Lp(a) levels were associated with increased ischemic stroke risk, primarily among individuals without AF but not in those with AF.
|Alternate Journal||J Am Heart Assoc|
|PubMed Central ID||PMC5779047|
|Grant List||16EIA26410001 / AHA / American Heart Association-American Stroke Association / United States|