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Diabetes-related factors and abdominal aortic aneurysm events: the Atherosclerotic Risk in Communities Study.

TitleDiabetes-related factors and abdominal aortic aneurysm events: the Atherosclerotic Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2018
AuthorsKubota Y, Folsom AR, Pankow JS, Wagenknecht LE
Secondary AuthorsTang W
JournalAnn Epidemiol
Volume28
Issue2
Pagination102-106.e1
Date Published2018 02
ISSN1873-2585
KeywordsAortic Aneurysm, Abdominal, Blood Glucose, Cholesterol, HDL, Diabetes Mellitus, Female, Follow-Up Studies, Humans, Hypertension, Male, Metabolic Syndrome, Middle Aged, Obesity, Abdominal
Abstract

PURPOSE: To test the hypothesis that diabetes-related factors (metabolic syndrome [MetS], glucose, insulin, and leptin) are inversely associated with abdominal aortic aneurysm (AAA) risk.

METHODS: We followed 13,736 participants, aged 45-64 years, without prior AAA surgery at baseline (1987-1989), for AAA occurrence through 2011. Hazard ratios (HRs) and their 95% confidence intervals (CIs) of AAA were calculated using Cox regression.

RESULTS: During 275,054 person-years of follow-up, we identified 518 AAA events. Fasting serum glucose was associated inversely with AAA risk (HR [95% CI] per one unit increment in log(glucose), 0.54 [0.36-0.80]), but fasting insulin was not associated with AAA. Plasma leptin was also associated inversely with AAA occurrence (HR [95% CI] per one unit increment in log(leptin), 0.83 [0.71-0.98]). Compared with individuals without MetS, those with MetS had increased risk of AAA (HR [95% CI], 1.24 [1.04-1.48]). Among individuals with or without diabetes, the HRs increased monotonically with a greater number of non-glucose MetS components.

CONCLUSIONS: Diabetes, fasting glucose, and plasma leptin were inversely associated with risk of AAA. In contrast, the MetS was associated with increased risk of AAA, due to the influence of the non-glucose MetS components.

DOI10.1016/j.annepidem.2017.12.003
Alternate JournalAnn Epidemiol
PubMed ID29277551
PubMed Central IDPMC5813832
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
R01 HL103695 / HL / NHLBI NIH HHS / United States