Title | Diabetes-related factors and abdominal aortic aneurysm events: the Atherosclerotic Risk in Communities Study. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Kubota Y, Folsom AR, Pankow JS, Wagenknecht LE |
Secondary Authors | Tang W |
Journal | Ann Epidemiol |
Volume | 28 |
Issue | 2 |
Pagination | 102-106.e1 |
Date Published | 2018 02 |
ISSN | 1873-2585 |
Keywords | Aortic Aneurysm, Abdominal, Blood Glucose, Cholesterol, HDL, Diabetes Mellitus, Female, Follow-Up Studies, Humans, Hypertension, Male, Metabolic Syndrome, Middle Aged, Obesity, Abdominal |
Abstract | PURPOSE: To test the hypothesis that diabetes-related factors (metabolic syndrome [MetS], glucose, insulin, and leptin) are inversely associated with abdominal aortic aneurysm (AAA) risk. METHODS: We followed 13,736 participants, aged 45-64 years, without prior AAA surgery at baseline (1987-1989), for AAA occurrence through 2011. Hazard ratios (HRs) and their 95% confidence intervals (CIs) of AAA were calculated using Cox regression. RESULTS: During 275,054 person-years of follow-up, we identified 518 AAA events. Fasting serum glucose was associated inversely with AAA risk (HR [95% CI] per one unit increment in log(glucose), 0.54 [0.36-0.80]), but fasting insulin was not associated with AAA. Plasma leptin was also associated inversely with AAA occurrence (HR [95% CI] per one unit increment in log(leptin), 0.83 [0.71-0.98]). Compared with individuals without MetS, those with MetS had increased risk of AAA (HR [95% CI], 1.24 [1.04-1.48]). Among individuals with or without diabetes, the HRs increased monotonically with a greater number of non-glucose MetS components. CONCLUSIONS: Diabetes, fasting glucose, and plasma leptin were inversely associated with risk of AAA. In contrast, the MetS was associated with increased risk of AAA, due to the influence of the non-glucose MetS components. |
DOI | 10.1016/j.annepidem.2017.12.003 |
Alternate Journal | Ann Epidemiol |
PubMed ID | 29277551 |
PubMed Central ID | PMC5813832 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States R01 HL103695 / HL / NHLBI NIH HHS / United States |