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Retinal microvascular signs and incidence of abdominal aortic aneurysm: The Atherosclerosis Risk in Communities Study.

TitleRetinal microvascular signs and incidence of abdominal aortic aneurysm: The Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2018
AuthorsFolsom AR, Lutsey PL, Klein R, Klein BE
Secondary AuthorsTang W
JournalOphthalmic Epidemiol
Volume25
Issue3
Pagination246-249
Date Published2018 06
ISSN1744-5086
KeywordsAortic Aneurysm, Abdominal, Arterioles, Atherosclerosis, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Population Surveillance, Prospective Studies, Retinal Diseases, Retinal Vessels, Risk Assessment, Risk Factors, United States, Venules
Abstract

PURPOSE: To test the hypothesis that retinal microvascular abnormalities known to predict other cardiovascular diseases are associated prospectively with risk of abdominal aortic aneurysm. The rationale is that aortic aneurysm involves small vessel pathology that parallels, to some degree, retinal vasculopathy.

METHODS: In 1993-1995, the Atherosclerosis Risk in Communities (ARIC) Study, a prospective population-based cohort, took retinal photographs of a randomly selected eye of 10,911 ARIC participants (initial mean age 60 years). Staff centrally graded the photographs using central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) indices. We followed participants for incidence of abdominal aortic aneurysm (n = 378 events), measured via medical record linkage from 1993-1995 through 2011.

RESULTS: Wider venular diameters were associated with increased incidence of abdominal aortic aneurysm, with the hazard ratio (95% CI) being 1.61 (1.20, 2.16) for the highest versus lowest quartile of CRVE. However, adjustment for other abdominal aortic aneurysm risk factors, particularly smoking, eliminated the association of CRVE with abdominal aortic aneurysm. CRAE and frank retinopathy showed no association with abdominal aortic aneurysm incidence.

CONCLUSION: This prospective study found that retinal vascular diameters and retinopathy are not associated with incidence of abdominal aortic aneurysm.

DOI10.1080/09286586.2017.1418387
Alternate JournalOphthalmic Epidemiol
PubMed ID29281316
PubMed Central IDPMC6095136
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
R01 HL103695 / HL / NHLBI NIH HHS / United States