Title | Hemoglobin, Albuminuria, and Kidney Function in Cardiovascular Risk: The ARIC (Atherosclerosis Risk in Communities) Study. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Ishigami J, Grams ME, Naik RP, Caughey MC, Loehr LR, Uchida S, Coresh JJ |
Secondary Authors | Matsushita K |
Journal | J Am Heart Assoc |
Volume | 7 |
Issue | 2 |
Date Published | 2018 01 12 |
ISSN | 2047-9980 |
Keywords | Albuminuria, Anemia, Biomarkers, Cardiovascular Diseases, Creatinine, Cross-Sectional Studies, Female, Glomerular Filtration Rate, Hemoglobins, Humans, Incidence, Kidney, Longitudinal Studies, Male, Middle Aged, Prevalence, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Serum Albumin, Human, Time Factors, United States |
Abstract | BACKGROUND: Reduced estimated glomerular filtration rate (eGFR) and elevated urinary albumin-to-creatinine ratio (ACR) individually increase risk of cardiovascular disease (CVD). We hypothesized that these associations are stronger among people with abnormal (both low and high) hemoglobin levels. METHODS AND RESULTS: Using 5801 participants with available hemoglobin measures of the ARIC (Atherosclerosis Risk in Community) study in 1996-1998, we explored the cross-sectional association of eGFR and ACR with hemoglobin levels and their longitudinal associations with CVD (heart failure, coronary heart disease, and stroke) risk through 2013. At baseline, 8.8% had anemia ( CONCLUSIONS: Kidney function, albuminuria, and anemia were correlated and independently associated with CVD risk. Correlation and potential interaction for atherosclerotic CVD between albuminuria and high hemoglobin deserve further investigation. |
DOI | 10.1161/JAHA.117.007209 |
Alternate Journal | J Am Heart Assoc |
PubMed ID | 29330257 |
PubMed Central ID | PMC5850152 |
Grant List | T32 HL007024 / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States HHSN268201100012C / HL / NHLBI NIH HHS / United States |