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Hemoglobin, Albuminuria, and Kidney Function in Cardiovascular Risk: The ARIC (Atherosclerosis Risk in Communities) Study.

TitleHemoglobin, Albuminuria, and Kidney Function in Cardiovascular Risk: The ARIC (Atherosclerosis Risk in Communities) Study.
Publication TypeJournal Article
Year of Publication2018
AuthorsIshigami J, Grams ME, Naik RP, Caughey MC, Loehr LR, Uchida S, Coresh JJ
Secondary AuthorsMatsushita K
JournalJ Am Heart Assoc
Volume7
Issue2
Date Published2018 01 12
ISSN2047-9980
KeywordsAlbuminuria, Anemia, Biomarkers, Cardiovascular Diseases, Creatinine, Cross-Sectional Studies, Female, Glomerular Filtration Rate, Hemoglobins, Humans, Incidence, Kidney, Longitudinal Studies, Male, Middle Aged, Prevalence, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Serum Albumin, Human, Time Factors, United States
Abstract

BACKGROUND: Reduced estimated glomerular filtration rate (eGFR) and elevated urinary albumin-to-creatinine ratio (ACR) individually increase risk of cardiovascular disease (CVD). We hypothesized that these associations are stronger among people with abnormal (both low and high) hemoglobin levels.

METHODS AND RESULTS: Using 5801 participants with available hemoglobin measures of the ARIC (Atherosclerosis Risk in Community) study in 1996-1998, we explored the cross-sectional association of eGFR and ACR with hemoglobin levels and their longitudinal associations with CVD (heart failure, coronary heart disease, and stroke) risk through 2013. At baseline, 8.8% had anemia (

CONCLUSIONS: Kidney function, albuminuria, and anemia were correlated and independently associated with CVD risk. Correlation and potential interaction for atherosclerotic CVD between albuminuria and high hemoglobin deserve further investigation.
DOI10.1161/JAHA.117.007209
Alternate JournalJ Am Heart Assoc
PubMed ID29330257
PubMed Central IDPMC5850152
Grant ListT32 HL007024 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States