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Periodontal Disease, Regular Dental Care Use, and Incident Ischemic Stroke.

TitlePeriodontal Disease, Regular Dental Care Use, and Incident Ischemic Stroke.
Publication TypeJournal Article
Year of Publication2018
AuthorsSen S, Giamberardino LD, Moss K, Morelli T, Rosamond WD, Gottesman RF, Beck J
Secondary AuthorsOffenbacher S
JournalStroke
Volume49
Issue2
Pagination355-362
Date Published2018 02
ISSN1524-4628
KeywordsAtherosclerosis, Brain Ischemia, Cohort Studies, Dental Care, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Periodontal Diseases, Risk Factors, Stroke
Abstract

BACKGROUND AND PURPOSE: Periodontal disease is independently associated with cardiovascular disease. Identification of periodontal disease as a risk factor for incident ischemic stroke raises the possibility that regular dental care utilization may reduce the stroke risk.

METHODS: In the ARIC (Atherosclerosis Risk in Communities) study, pattern of dental visits were classified as regular or episodic dental care users. In the ancillary dental ARIC study, selected subjects from ARIC underwent fullmouth periodontal measurements collected at 6 sites per tooth and classified into 7 periodontal profile classes (PPCs).

RESULTS: In the ARIC study 10 362 stroke-free participants, 584 participants had incident ischemic strokes over a 15-year period. In the dental ARIC study, 6736 dentate subjects were assessed for periodontal disease status using PPC with a total of 299 incident ischemic strokes over the 15-year period. The 7 levels of PPC showed a trend toward an increased stroke risk (χ trend

CONCLUSIONS: We confirm an independent association between periodontal disease and incident stroke risk, particularly cardioembolic and thrombotic stroke subtype. Further, we report that regular dental care utilization may lower this risk for stroke.

DOI10.1161/STROKEAHA.117.018990
Alternate JournalStroke
PubMed ID29335336
PubMed Central IDPMC5780242
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
R01 MD009738 / MD / NIMHD NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
K23 DE025093 / DE / NIDCR NIH HHS / United States
R01 DE011551 / DE / NIDCR NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States