Title | Periodontal Disease, Regular Dental Care Use, and Incident Ischemic Stroke. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Sen S, Giamberardino LD, Moss K, Morelli T, Rosamond WD, Gottesman RF, Beck J |
Secondary Authors | Offenbacher S |
Journal | Stroke |
Volume | 49 |
Issue | 2 |
Pagination | 355-362 |
Date Published | 2018 02 |
ISSN | 1524-4628 |
Keywords | Atherosclerosis, Brain Ischemia, Cohort Studies, Dental Care, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Periodontal Diseases, Risk Factors, Stroke |
Abstract | BACKGROUND AND PURPOSE: Periodontal disease is independently associated with cardiovascular disease. Identification of periodontal disease as a risk factor for incident ischemic stroke raises the possibility that regular dental care utilization may reduce the stroke risk. METHODS: In the ARIC (Atherosclerosis Risk in Communities) study, pattern of dental visits were classified as regular or episodic dental care users. In the ancillary dental ARIC study, selected subjects from ARIC underwent fullmouth periodontal measurements collected at 6 sites per tooth and classified into 7 periodontal profile classes (PPCs). RESULTS: In the ARIC study 10 362 stroke-free participants, 584 participants had incident ischemic strokes over a 15-year period. In the dental ARIC study, 6736 dentate subjects were assessed for periodontal disease status using PPC with a total of 299 incident ischemic strokes over the 15-year period. The 7 levels of PPC showed a trend toward an increased stroke risk (χ trend CONCLUSIONS: We confirm an independent association between periodontal disease and incident stroke risk, particularly cardioembolic and thrombotic stroke subtype. Further, we report that regular dental care utilization may lower this risk for stroke. |
DOI | 10.1161/STROKEAHA.117.018990 |
Alternate Journal | Stroke |
PubMed ID | 29335336 |
PubMed Central ID | PMC5780242 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States R01 MD009738 / MD / NIMHD NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States K23 DE025093 / DE / NIDCR NIH HHS / United States R01 DE011551 / DE / NIDCR NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States |