|Title||Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Michaud DS, Lu J, Peacock-Villada AY, Barber JR, Joshu CE, Prizment AE, Beck JD, Offenbacher S|
|Secondary Authors||Platz EA|
|Journal||J Natl Cancer Inst|
|Date Published||2018 08 01|
|Keywords||African Continental Ancestry Group, Age Factors, Aged, Cohort Studies, Diagnosis, Oral, European Continental Ancestry Group, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasms, Periodontal Diseases, Periodontitis, Risk Factors, Severity of Illness Index|
Background: While evidence is increasingly consistent with a positive association between periodontitis and cancer risk, most studies have relied on self-reported periodontitis. In this study, we prospectively evaluated the association of periodontal disease severity with cancer risk in black and white older adults in a cohort study that included a dental examination.
Methods: Included were 7466 participants in the Atherosclerosis Risk in Communities study cohort who at visit 4 (1996-1998) reported being edentulous or underwent the dental examination. Probing depth and gingival recession were measured at six sites on all teeth; these measurements were used to define periodontal disease severity. Incident cancers (n = 1648) and cancer deaths (n = 547) were ascertained during a median of 14.7 years of follow-up. All statistical tests were two-sided.
Results: An increased risk of total cancer (hazard ratio [HR] = 1.24, 95% confidence interval [CI] = 1.07 to 1.44, Ptrend = .004) was observed for severe periodontitis (>30% of sites with attachment loss >3 mm) compared with no/mild periodontitis (3 mm), adjusting for smoking and other factors. Strong associations were observed for lung cancer (HR = 2.33, 95% CI = 1.51 to 3.60, Ptrend
Conclusions: This study provides additional evidence that cancer risk, especially for lung and colorectal cancer, is elevated in individuals with periodontitis. Additional research is needed to understand cancer site-specific and racial differences in findings.
|Alternate Journal||J Natl Cancer Inst|
|PubMed Central ID||PMC6093423|
|Grant List||R01 CA166150 / CA / NCI NIH HHS / United States |
P30 CA006973 / CA / NCI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
U01 CA164975 / CA / NCI NIH HHS / United States