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Ideal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients.

TitleIdeal Cardiovascular Health and the Prevalence and Severity of Aortic Stenosis in Elderly Patients.
Publication TypeJournal Article
Year of Publication2018
AuthorsSengeløv M, Cheng S, Biering-Sørensen T, Matsushita K, Konety S, Solomon SD, Folsom AR
Secondary AuthorsShah AM
JournalJ Am Heart Assoc
Volume7
Issue3
Date Published2018 02 03
ISSN2047-9980
KeywordsAged, Aged, 80 and over, Aortic Valve, Aortic Valve Stenosis, Biomarkers, Blood Glucose, Blood Pressure, Body Mass Index, Calcinosis, Cholesterol, Echocardiography, Doppler, Exercise, Female, Geriatric Assessment, Health Status, Humans, Life Style, Male, Prevalence, Protective Factors, Risk Assessment, Risk Factors, Risk Reduction Behavior, Severity of Illness Index, Smoking, Smoking Cessation, United States
Abstract

BACKGROUND: The relationship between ideal cardiovascular health reflected in the cardiovascular health score (CVHS) and valvular heart disease is not known. The purpose of this study was to determine the association of CVHS attainment through midlife to late life with aortic stenosis prevalence and severity in late life.

METHODS AND RESULTS: The following 6 ideal cardiovascular health metrics were assessed in ARIC (Atherosclerosis Risk in Communities) Study participants at 5 examination visits between 1987 and 2013 (visits 1-4 in 1987-1998 and visit 5 in 2011-2013): smoking, body mass index, total cholesterol, blood pressure, physical activity, and blood glucose. Percentage attained CVHS was calculated in 6034 participants as the sum of CVHS at each visit/the maximum possible score. Aortic stenosis was assessed by echocardiography at visit 5 on the basis of the peak aortic valve velocity. Aortic stenosis was categorized sclerosis, mild stenosis, and moderate-to-severe stenosis. Mean age was 76±5 years, 42% were men, and 22% were black. Mean percentage attained CVHS was 63±14%, and the prevalence of aortic stenosis stages were 15.9% for sclerosis, 4.3% for mild stenosis, and 0.7% for moderate-to-severe stenosis. Worse percentage attained CVHS was associated with higher prevalence of aortic sclerosis (

CONCLUSIONS: Greater attainment of ideal cardiovascular health in midlife to late life is associated with a lower prevalence of aortic sclerosis and stenosis in late life in a large cohort of older adults.

DOI10.1161/JAHA.117.007234
Alternate JournalJ Am Heart Assoc
PubMed ID29431107
PubMed Central IDPMC5850241
Grant ListR01 HL134168 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
K08 HL116792 / HL / NHLBI NIH HHS / United States
R01 HL135008 / HL / NHLBI NIH HHS / United States
R01 HL131532 / HL / NHLBI NIH HHS / United States