Pulse lineResearch With Heart Logo

Association of lipoprotein-associated phospholipase A and risk of incident atrial fibrillation: Findings from 3 cohorts.

TitleAssociation of lipoprotein-associated phospholipase A and risk of incident atrial fibrillation: Findings from 3 cohorts.
Publication TypeJournal Article
Year of Publication2018
AuthorsGarg PK, Bartz TM, Norby FL, Jorgensen NW, McClelland RL, Ballantyne CM, Chen LYee, Gottdiener JS, Greenland P, Hoogeveen RC, Jenny NS, Kizer JR, Rosenson RS, Soliman EZ, Cushman M, Alonso A
Secondary AuthorsHeckbert SR
JournalAm Heart J
Volume197
Pagination62-69
Date Published2018 03
ISSN1097-6744
Keywords1-Alkyl-2-acetylglycerophosphocholine Esterase, Aged, Aged, 80 and over, Atrial Fibrillation, Cohort Studies, Correlation of Data, Electrocardiography, Female, Follow-Up Studies, Humans, Incidence, Inflammation, Male, Middle Aged, Platelet Activation, Risk Assessment, Risk Factors, United States
Abstract

BACKGROUND: Multiple prospective studies have established an association between inflammation and higher risk of atrial fibrillation (AF), but the association between lipoprotein-associated phospholipase A (Lp-PLA) mass and activity and incident AF has not been extensively evaluated.

METHODS: Using data from 10,794 Atherosclerosis Risk In Communities (ARIC) study participants aged 53-75 years, 5,181 Cardiovascular Health Study (CHS) participants aged 65 to 100 years, and 5,425 Multi-Ethnic Study of Atherosclerosis (MESA) participants aged 45-84 years, we investigated the association between baseline Lp-PLA levels and the risk of developing AF. Incident AF was identified in each cohort by follow-up visit electrocardiograms, hospital discharge coding of AF, or Medicare claims data.

RESULTS: Over a mean of 13.1, 11.5, and 10.0 years of follow-up, 1,439 (13%), 2,084 (40%), and 615 (11%) incident AF events occurred in ARIC, CHS, and MESA, respectively. In adjusted analyses, each SD increment in Lp-PLA activity was associated with incident AF in both ARIC (hazard ratio [HR] 1.13, 95% CI 1.06-1.20) and MESA (HR 1.24, 95% CI 1.05-1.46). Each SD increment in Lp-PLA mass was also associated with incident AF in MESA (HR 1.25, 95% CI 1.11-1.41). No significant associations were observed among CHS participants.

CONCLUSIONS: Although higher Lp-PLA mass and activity were associated with development of AF in ARIC and MESA, this relationship was not observed in CHS, a cohort of older individuals.

DOI10.1016/j.ahj.2017.11.010
Alternate JournalAm Heart J
PubMed ID29447785
PubMed Central IDPMC5860682
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
U01 HL130114 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
16EIA26410001 / AHA / American Heart Association-American Stroke Association / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States