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American Heart Association's Life's Simple 7 at Middle Age and Prognosis After Myocardial Infarction in Later Life.

TitleAmerican Heart Association's Life's Simple 7 at Middle Age and Prognosis After Myocardial Infarction in Later Life.
Publication TypeJournal Article
Year of Publication2018
AuthorsMok Y, Sang Y, Ballew SH, Rebholz CM, Rosamond WD, Heiss G, Folsom AR, Coresh JJ
Secondary AuthorsMatsushita K
JournalJ Am Heart Assoc
Date Published2018 02 17
KeywordsAdiposity, Age Factors, American Heart Association, Biomarkers, Blood Pressure, Body Mass Index, Cholesterol, Diet, Healthy, Exercise, Glucose, Health Status, Healthy Lifestyle, Humans, Incidence, Male, Middle Aged, Myocardial Infarction, Prognosis, Prospective Studies, Protective Factors, Risk Assessment, Risk Factors, Risk Reduction Behavior, Secondary Prevention, Smoking, Smoking Cessation, Time Factors, United States

BACKGROUND: The American Heart Association recommends focusing on 7 health factors (Life's Simple 7) for primordial prevention of cardiovascular health. However, whether greater adherence to Life's Simple 7 in midlife improves prognosis after myocardial infarction (MI) in later life is unknown.

METHODS AND RESULTS: In 1277 participants who developed MI during the ARIC (Atherosclerosis Risk in Communities) Study follow-up, a 14-point score of Life's Simple 7 was constructed according to the status (2 points for ideal, 1 point for intermediate, and 0 points for poor) of each of 7 factors (smoking, adiposity, physical activity, diet, total cholesterol, blood pressure, and fasting glucose) at baseline (1987-1989). Hazard ratios for composite and individual adverse outcomes of all-cause mortality, cardiovascular mortality, recurrent MI, heart failure, and stroke were calculated according to Life's Simple 7 score. During a median follow-up of 3.3 years, 918 participants (72%) had subsequent adverse outcomes after MI. Life's Simple 7 score at middle age was inversely associated with adverse outcomes after MI (adjusted hazard ratios of composite outcome, 0.57 [95% confidence interval, 0.39-0.84] if score is ≥10, 0.78 [95% confidence interval, 0.57-1.07] if score is 7-9, and 0.82 [95% confidence interval, 0.60-1.11] if score is 4-6 versus ≤3). The association was largely independent of access to care and MI severity. Individual factors related to better prognosis after MI were ideal nonsmoking, body mass index, blood pressure, and fasting glucose.

CONCLUSIONS: Optimal Life's Simple 7 at middle age was associated with better prognosis after MI in later life. Our findings suggest a secondary prevention benefit of having better cardiovascular health status in midlife.

Alternate JournalJ Am Heart Assoc
PubMed ID29455158
PubMed Central IDPMC5850193
Grant ListK01 DK107782 / DK / NIDDK NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States