Title | A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Sung YJ, Winkler TW, Fuentes Lde Las, et al. |
Secondary Authors | Chasman DI |
Corporate Authors | CHARGE Neurology Working Group, COGENT-Kidney Consortium, GIANT consortium, LifeLines Cohort Study |
Journal | Am J Hum Genet |
Volume | 102 |
Issue | 3 |
Pagination | 375-400 |
Date Published | 2018 03 01 |
ISSN | 1537-6605 |
Keywords | Blood Pressure, Cohort Studies, Continental Population Groups, Diastole, Epistasis, Genetic, Female, Genetic Loci, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Reproducibility of Results, Smoking, Systole |
Abstract | Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined ∼18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p |
DOI | 10.1016/j.ajhg.2018.01.015 |
Alternate Journal | Am J Hum Genet |
PubMed ID | 29455858 |
PubMed Central ID | PMC5985266 |
Grant List | U01 AG009740 / AG / NIA NIH HHS / United States G0700931 / MRC_ / Medical Research Council / United Kingdom R00 HL130580 / HL / NHLBI NIH HHS / United States MR/L01632X/1 / MRC_ / Medical Research Council / United Kingdom MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom P30 DK063491 / DK / NIDDK NIH HHS / United States P30 DK072488 / DK / NIDDK NIH HHS / United States MC_PC_U127561128 / MRC_ / Medical Research Council / United Kingdom U01 DK062370 / DK / NIDDK NIH HHS / United States U54 GM115428 / GM / NIGMS NIH HHS / United States K01 HL135405 / HL / NHLBI NIH HHS / United States MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom G9521010 / MRC_ / Medical Research Council / United Kingdom R01 AG054076 / AG / NIA NIH HHS / United States MR/K002414/1 / MRC_ / Medical Research Council / United Kingdom U01 HL130114 / HL / NHLBI NIH HHS / United States SP/13/2/30111 / BHF_ / British Heart Foundation / United Kingdom MC_UP_1605/7 / MRC_ / Medical Research Council / United Kingdom K25 HL121091 / HL / NHLBI NIH HHS / United States MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom G0601966 / MRC_ / Medical Research Council / United Kingdom MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom R01 HL118305 / HL / NHLBI NIH HHS / United States R01 DK062370 / DK / NIDDK NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom R21 HL123677 / HL / NHLBI NIH HHS / United States MR/K006584/1 / MRC_ / Medical Research Council / United Kingdom U01 AG023746 / AG / NIA NIH HHS / United States P30 DK020572 / DK / NIDDK NIH HHS / United States MC_UU_12015/5 / MRC_ / Medical Research Council / United Kingdom R01 MD012765 / MD / NIMHD NIH HHS / United States P30 AG010129 / AG / NIA NIH HHS / United States R01 HL117078 / HL / NHLBI NIH HHS / United States P01 CA196569 / CA / NCI NIH HHS / United States UL1 TR001881 / TR / NCATS NIH HHS / United States T32 HL007055 / HL / NHLBI NIH HHS / United States G0600237 / MRC_ / Medical Research Council / United Kingdom |