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In search of appropriate measures of periodontal status: The Periodontal Profile Phenotype (P ) system.

TitleIn search of appropriate measures of periodontal status: The Periodontal Profile Phenotype (P ) system.
Publication TypeJournal Article
Year of Publication2018
AuthorsBeck JD, Moss KL, Morelli T
Secondary AuthorsOffenbacher S
JournalJ Periodontol
Volume89
Issue2
Pagination166-175
Date Published2018 02
ISSN1943-3670
KeywordsDentition, Humans, Periodontal Index, Periodontitis, Phenotype, Tooth Loss
Abstract

BACKGROUND: This paper focuses on Periodontal Profile Class (PPC), a component of the Periodontal Profile Phenotype (P ) System that may be more representative of the periodontitis phenotype than current case definitions of periodontitis. Data illustrate the unique aspects of the PPC compared with other commonly used periodontal classification indices.

METHODS: Latent Class Analysis (LCA) identified discrete classes of individuals grouped by tooth-level clinical parameters. The analysis defined seven distinct periodontal profile classes (PPC A through G) and seven distinct tooth profile classes (TPC A through G). This LCA classification was an entirely data-derived agnostic process without any preconceived presumptions of what constituted disease.

RESULTS: Comparing the PPC with the Centers for Disease Control/American Academy of Periodontology (CDC/AAP) and European indices, the PPC is unique in that it contains four disease classes not traditionally used. Less than half of individuals classified as Healthy by both the CDC/AAP and European indices were Healthy using the PPC. About 25% of those classified as Severe by CDC/AAP and European indices were PPC-Severe. The remainder spread out over the High Gingival Index, Posterior Disease, Tooth Loss, and Severe Tooth Loss phenotypes.

CONCLUSIONS: The PPC classification provides a significant departure from the traditional clinical case status indices that have been used, but has resulted in clinical phenotypes that are quite familiar to most clinicians who take notice of the distribution of missing teeth, areas of recession, diminished periodontal support, and other aspects of the dentition while conducting a periodontal examination. The mutually exclusive categories provided by the PPC system provide periodontal clinical summaries that can be an important component of precision dentistry.

DOI10.1002/JPER.17-0424
Alternate JournalJ Periodontol
PubMed ID29520827
PubMed Central IDPMC6125155
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
K23 DE025093 / DE / NIDCR NIH HHS / United States
UL1 TR001111 / TR / NCATS NIH HHS / United States
T90 DE021986 / DE / NIDCR NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
R01 DE023836 / DE / NIDCR NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
R01 DE021418 / DE / NIDCR NIH HHS / United States