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Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

TitleRefining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
Publication TypeJournal Article
Year of Publication2018
AuthorsMahajan A, Wessel J, Willems SM, et al.
Secondary AuthorsMcCarthy MI
Corporate AuthorsExomeBP Consortium, MAGIC Consortium, GIANT consortium
JournalNat Genet
Volume50
Issue4
Pagination559-571
Date Published2018 04
ISSN1546-1718
KeywordsAlleles, Chromosome Mapping, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Male, Whole Exome Sequencing
Abstract

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P 

DOI10.1038/s41588-018-0084-1
Alternate JournalNat Genet
PubMed ID29632382
PubMed Central IDPMC5898373
Grant ListG0601463 / MRC_ / Medical Research Council / United Kingdom
RG/13/13/30194 / BHF_ / British Heart Foundation / United Kingdom
U01 DK085545 / DK / NIDDK NIH HHS / United States
R01 DK098032 / DK / NIDDK NIH HHS / United States
R35 HL135824 / HL / NHLBI NIH HHS / United States
MR/L003120/1 / MRC_ / Medical Research Council / United Kingdom
P30 DK063491 / DK / NIDDK NIH HHS / United States
K24 DK080140 / DK / NIDDK NIH HHS / United States
U01 DK078616 / DK / NIDDK NIH HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
P30 DK116074 / DK / NIDDK NIH HHS / United States
U54 GM115428 / GM / NIGMS NIH HHS / United States
R01 DK093757 / DK / NIDDK NIH HHS / United States
R01 DK078616 / DK / NIDDK NIH HHS / United States
MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
U01 HL130114 / HL / NHLBI NIH HHS / United States
MR/K023241/1 / MRC_ / Medical Research Council / United Kingdom
MR/L020149/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK072193 / DK / NIDDK NIH HHS / United States
R00 HL130580 / HL / NHLBI NIH HHS / United States
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
R01 HL119443 / HL / NHLBI NIH HHS / United States
R01 DK062370 / DK / NIDDK NIH HHS / United States
U01 DK105535 / DK / NIDDK NIH HHS / United States
MR/S003746/1 / MRC_ / Medical Research Council / United Kingdom
MC_PC_U127561128 / MRC_ / Medical Research Council / United Kingdom
P30 DK020572 / DK / NIDDK NIH HHS / United States
RG/14/5/30893 / BHF_ / British Heart Foundation / United Kingdom
MR/K007017/1 / MRC_ / Medical Research Council / United Kingdom
P20 GM121334 / GM / NIGMS NIH HHS / United States
MC_PC_13040 / MRC_ / Medical Research Council / United Kingdom
UL1 TR001881 / TR / NCATS NIH HHS / United States
T32 HL007055 / HL / NHLBI NIH HHS / United States
G0601261 / MRC_ / Medical Research Council / United Kingdom