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Adiposity, body composition and ventricular-arterial stiffness in the elderly: the Atherosclerosis Risk in Communities Study.

TitleAdiposity, body composition and ventricular-arterial stiffness in the elderly: the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2018
AuthorsFernandes-Silva MM, Shah AM, Claggett B, Cheng S, Tanaka H, Silvestre OM, Nadruz W, Borlaug BA
Secondary AuthorsSolomon SD
JournalEur J Heart Fail
Volume20
Issue8
Pagination1191-1201
Date Published2018 08
ISSN1879-0844
KeywordsAdiposity, Aged, Aged, 80 and over, Atherosclerosis, Body Mass Index, Echocardiography, Female, Heart Ventricles, Humans, Male, Middle Aged, Obesity, Pulse Wave Analysis, Risk Factors, Vascular Stiffness
Abstract

AIM: Weight gain appears to accelerate age-related ventricular-arterial stiffening, which has been implicated in the development of heart failure (HF), but it is unclear whether body fat accumulation underpins this association. We evaluated the relationship of adiposity, using measures of body composition, with ventricular-arterial stiffness among the elderly in the community.

METHODS AND RESULTS: Adiposity was accessed through body mass index (BMI), waist circumference, and body fat percentage. We studied the association of these measures with carotid-femoral pulse wave velocity (cfPWV), arterial elastance index (EaI), left ventricular (LV) end-systolic elastance index (EesI) and LV end-diastolic elastance index (EedI) in 5520 community-based, elderly Atherosclerosis Risk in Communities (ARIC) Study participants, who underwent echocardiography between 2011 and 2013. BMI and waist circumference were directly associated with EaI, EedI and EesI even after adjusting for age, sex, race, hypertension, diabetes mellitus, heart rate, prevalent coronary heart disease and HF. After further adjustment for BMI, body fat percentage demonstrated significant independent linear relationships with EaI [standardized beta coefficient (╬▓)=0.17, P

CONCLUSION: In this biracial community-based cohort, increased adiposity was associated with increased ventricular-arterial stiffness among the elderly and suggests a potential mechanism by which obesity might contribute to the development of HF.

DOI10.1002/ejhf.1188
Alternate JournalEur J Heart Fail
PubMed ID29663586
PubMed Central IDPMC6685543
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
K08 HL116792 / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100005C / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States
HHSN268201100010C / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States
R01 HL135008 / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States
R00 HL107642 / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States
R00 HL107642 / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100012C / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States
R01 AG053938 / NIA NIH HHS / National Institute on Aging / United States
R01 HL134168 / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States
K08 HL116792 / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States
R01 HL131532 / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States
HHSN268201100006C / NHLBI NIH HHS / National Heart, Lung, and Blood Institute / United States