Title | Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Knopman DS, Gottesman RF, Sharrett ARichey, Tapia AL, DavisThomas S, B Windham G, Coker L, Schneider ALC, Alonso A, Coresh JJ, Albert MS |
Secondary Authors | Mosley TH |
Journal | Alzheimers Dement |
Volume | 14 |
Issue | 11 |
Pagination | 1406-1415 |
Date Published | 2018 11 |
ISSN | 1552-5279 |
Keywords | Aged, Aged, 80 and over, Cardiovascular Diseases, Cognitive Dysfunction, Dementia, Female, Humans, Male, Middle Aged, Prevalence, Risk Factors |
Abstract | INTRODUCTION: The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood. METHODS: In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45-64 years. In 2011-2013, 20-25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM. RESULTS: In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late-life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model. DISCUSSION: Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition. |
DOI | 10.1016/j.jalz.2018.03.011 |
Alternate Journal | Alzheimers Dement |
PubMed ID | 29763593 |
PubMed Central ID | PMC6231996 |
Grant List | U01 HL096812 / HL / NHLBI NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States R01 HL070825 / HL / NHLBI NIH HHS / United States K24 AG052573 / AG / NIA NIH HHS / United States |