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Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study.

TitleMidlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2018
AuthorsKnopman DS, Gottesman RF, Sharrett ARichey, Tapia AL, DavisThomas S, B Windham G, Coker L, Schneider ALC, Alonso A, Coresh JJ, Albert MS
Secondary AuthorsMosley TH
JournalAlzheimers Dement
Volume14
Issue11
Pagination1406-1415
Date Published2018 11
ISSN1552-5279
KeywordsAged, Aged, 80 and over, Cardiovascular Diseases, Cognitive Dysfunction, Dementia, Female, Humans, Male, Middle Aged, Prevalence, Risk Factors
Abstract

INTRODUCTION: The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood.

METHODS: In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45-64 years. In 2011-2013, 20-25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM.

RESULTS: In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late-life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model.

DISCUSSION: Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.

DOI10.1016/j.jalz.2018.03.011
Alternate JournalAlzheimers Dement
PubMed ID29763593
PubMed Central IDPMC6231996
Grant ListU01 HL096812 / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
K24 AG052573 / AG / NIA NIH HHS / United States