Title | Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Davies G, Lam M, Harris SE, et al. |
Secondary Authors | Deary IJ |
Journal | Nat Commun |
Volume | 9 |
Issue | 1 |
Pagination | 2098 |
Date Published | 2018 05 29 |
ISSN | 2041-1723 |
Keywords | Adolescent, Adult, Aged, Aged, 80 and over, Cognition, Genetic Loci, Genetic Predisposition to Disease, Humans, Mental Disorders, Middle Aged, Multifactorial Inheritance, Neurodegenerative Diseases, Neurodevelopmental Disorders, Polymorphism, Single Nucleotide, Reaction Time, Young Adult |
Abstract | General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P |
DOI | 10.1038/s41467-018-04362-x |
Alternate Journal | Nat Commun |
PubMed ID | 29844566 |
PubMed Central ID | PMC5974083 |
Grant List | MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom MC_U147585827 / MRC_ / Medical Research Council / United Kingdom U01 AG009740 / AG / NIA NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States MC_UU_12011/2 / MRC_ / Medical Research Council / United Kingdom R01 MH085018 / MH / NIMH NIH HHS / United States MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom MR/S015132/1 / MRC_ / Medical Research Council / United Kingdom U01 HL096814 / HL / NHLBI NIH HHS / United States R01 AG055406 / AG / NIA NIH HHS / United States U01 AG052409 / AG / NIA NIH HHS / United States MC_UU_12011/4 / MRC_ / Medical Research Council / United Kingdom U01 AG049505 / AG / NIA NIH HHS / United States U01 HL096812 / HL / NHLBI NIH HHS / United States R01 NS017950 / NS / NINDS NIH HHS / United States R01 AG054076 / AG / NIA NIH HHS / United States R01 AG049789 / AG / NIA NIH HHS / United States RF1 AG015819 / AG / NIA NIH HHS / United States MC_QA137853 / MRC_ / Medical Research Council / United Kingdom U01 HL130114 / HL / NHLBI NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States MC_U147585819 / MRC_ / Medical Research Council / United Kingdom R01 HL105756 / HL / NHLBI NIH HHS / United States MC_UP_A620_1014 / MRC_ / Medical Research Council / United Kingdom P30 AG010161 / AG / NIA NIH HHS / United States R01 AG033193 / AG / NIA NIH HHS / United States MC_UP_A620_1017 / MRC_ / Medical Research Council / United Kingdom MC_UU_12011/1 / MRC_ / Medical Research Council / United Kingdom R01 HL070825 / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States P30 AG010129 / AG / NIA NIH HHS / United States MC_PC_17228 / MRC_ / Medical Research Council / United Kingdom BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom UL1 TR001881 / TR / NCATS NIH HHS / United States G0400491 / MRC_ / Medical Research Council / United Kingdom G0600237 / MRC_ / Medical Research Council / United Kingdom G0100594 / MRC_ / Medical Research Council / United Kingdom U54 GM115428 / GM / NIGMS NIH HHS / United States MC_U147585824 / MRC_ / Medical Research Council / United Kingdom BB/F022441/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom G0901461 / MRC_ / Medical Research Council / United Kingdom |