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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

TitleStudy of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
Publication TypeJournal Article
Year of Publication2018
AuthorsDavies G, Lam M, Harris SE, et al.
Secondary AuthorsDeary IJ
JournalNat Commun
Volume9
Issue1
Pagination2098
Date Published2018 05 29
ISSN2041-1723
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Cognition, Genetic Loci, Genetic Predisposition to Disease, Humans, Mental Disorders, Middle Aged, Multifactorial Inheritance, Neurodegenerative Diseases, Neurodevelopmental Disorders, Polymorphism, Single Nucleotide, Reaction Time, Young Adult
Abstract

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P 

DOI10.1038/s41467-018-04362-x
Alternate JournalNat Commun
PubMed ID29844566
PubMed Central IDPMC5974083
Grant ListMC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
MC_U147585827 / MRC_ / Medical Research Council / United Kingdom
U01 AG009740 / AG / NIA NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
MC_UU_12011/2 / MRC_ / Medical Research Council / United Kingdom
R01 MH085018 / MH / NIMH NIH HHS / United States
MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom
MR/S015132/1 / MRC_ / Medical Research Council / United Kingdom
U01 HL096814 / HL / NHLBI NIH HHS / United States
R01 AG055406 / AG / NIA NIH HHS / United States
U01 AG052409 / AG / NIA NIH HHS / United States
MC_UU_12011/4 / MRC_ / Medical Research Council / United Kingdom
U01 AG049505 / AG / NIA NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
R01 NS017950 / NS / NINDS NIH HHS / United States
R01 AG054076 / AG / NIA NIH HHS / United States
R01 AG049789 / AG / NIA NIH HHS / United States
RF1 AG015819 / AG / NIA NIH HHS / United States
MC_QA137853 / MRC_ / Medical Research Council / United Kingdom
U01 HL130114 / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
MC_U147585819 / MRC_ / Medical Research Council / United Kingdom
R01 HL105756 / HL / NHLBI NIH HHS / United States
MC_UP_A620_1014 / MRC_ / Medical Research Council / United Kingdom
P30 AG010161 / AG / NIA NIH HHS / United States
R01 AG033193 / AG / NIA NIH HHS / United States
MC_UP_A620_1017 / MRC_ / Medical Research Council / United Kingdom
MC_UU_12011/1 / MRC_ / Medical Research Council / United Kingdom
R01 HL070825 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
P30 AG010129 / AG / NIA NIH HHS / United States
MC_PC_17228 / MRC_ / Medical Research Council / United Kingdom
BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
UL1 TR001881 / TR / NCATS NIH HHS / United States
G0400491 / MRC_ / Medical Research Council / United Kingdom
G0600237 / MRC_ / Medical Research Council / United Kingdom
G0100594 / MRC_ / Medical Research Council / United Kingdom
U54 GM115428 / GM / NIGMS NIH HHS / United States
MC_U147585824 / MRC_ / Medical Research Council / United Kingdom
BB/F022441/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
G0901461 / MRC_ / Medical Research Council / United Kingdom