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Harmonization of Respiratory Data From 9 US Population-Based Cohorts: The NHLBI Pooled Cohorts Study.

TitleHarmonization of Respiratory Data From 9 US Population-Based Cohorts: The NHLBI Pooled Cohorts Study.
Publication TypeJournal Article
Year of Publication2018
AuthorsOelsner EC, Balte PP, Cassano PA, Couper DJ, Enright PL, Folsom AR, Hankinson J, Jacobs DR, Kalhan R, Kaplan R, Kronmal R, Lange L, Loehr LR, London SJ, Acien ANavas, Newman AB, O'Connor GT, Schwartz JE, Smith LJ, Yeh F, Zhang Y, Moran AE, Mwasongwe S, White WB, Yende S
Secondary AuthorsBarr GR
JournalAm J Epidemiol
Date Published2018 11 01
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Body Weights and Measures, Bronchiectasis, Chronic Disease, Cohort Studies, Continental Population Groups, Ethnic Groups, European Continental Ancestry Group, Female, Hispanic Americans, Hospitalization, Humans, Indians, North American, Inhalation Exposure, Lung Diseases, Obstructive, Male, Middle Aged, National Heart, Lung, and Blood Institute (U.S.), Phenotype, Respiratory Function Tests, Risk Factors, Smoking, Socioeconomic Factors, United States, Young Adult

Chronic lower respiratory diseases (CLRDs) are the fourth leading cause of death in the United States. To support investigations into CLRD risk determinants and new approaches to primary prevention, we aimed to harmonize and pool respiratory data from US general population-based cohorts. Data were obtained from prospective cohorts that performed prebronchodilator spirometry and were harmonized following 2005 ATS/ERS standards. In cohorts conducting follow-up for noncardiovascular events, CLRD events were defined as hospitalizations/deaths adjudicated as CLRD-related or assigned relevant administrative codes. Coding and variable names were applied uniformly. The pooled sample included 65,251 adults in 9 cohorts followed-up for CLRD-related mortality over 653,380 person-years during 1983-2016. Average baseline age was 52 years; 56% were female; 49% were never-smokers; and racial/ethnic composition was 44% white, 22% black, 28% Hispanic/Latino, and 5% American Indian. Over 96% had complete data on smoking, clinical CLRD diagnoses, and dyspnea. After excluding invalid spirometry examinations (13%), there were 105,696 valid examinations (median, 2 per participant). Of 29,351 participants followed for CLRD hospitalizations, median follow-up was 14 years; only 5% were lost to follow-up at 10 years. The NHLBI Pooled Cohorts Study provides a harmonization standard applied to a large, US population-based sample that may be used to advance epidemiologic research on CLRD.

Alternate JournalAm J Epidemiol
PubMed ID29982273
PubMed Central IDPMC6211239
Grant ListR01 HL077612 / HL / NHLBI NIH HHS / United States
R01 HL093081 / HL / NHLBI NIH HHS / United States
R21 HL121457 / HL / NHLBI NIH HHS / United States
R21 HL129924 / HL / NHLBI NIH HHS / United States
R01 HL109284 / HL / NHLBI NIH HHS / United States
K23 HL130627 / HL / NHLBI NIH HHS / United States
R01 HL122477 / HL / NHLBI NIH HHS / United States
P30 ES009089 / ES / NIEHS NIH HHS / United States