Title | Serum Vitamin D Concentrations and Cognitive Change Over 20 Years: The Atherosclerosis Risk in Communities Neurocognitive Study. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Schneider ALC, Zhao D, Lutsey PL, Gottesman RF, Sharrett ARichey, Rawlings AM, Alonso A, Knopman D, Mosley TH, Selvin E |
Secondary Authors | Michos ED |
Journal | Neuroepidemiology |
Volume | 51 |
Issue | 3-4 |
Pagination | 131-137 |
Date Published | 2018 |
ISSN | 1423-0208 |
Keywords | Aged, Atherosclerosis, Cognition, Cognitive Dysfunction, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Vitamin D |
Abstract | BACKGROUND/AIMS: 25-hydroxyvitamin D (25[OH]D) concentrations have been associated with cognitive decline and incident dementia in elderly populations; however, these relationships are susceptible to reverse causation. Less is known about the association of midlife 25(OH)D with long-term cognitive decline. METHODS: This was a prospective cohort study of 13,044 participants (mean age 57 years at baseline) in the Atherosclerosis Risk in Communities Study. 25(OH)D was measured from serum collected at baseline (1990-1992) using liquid chromatography tandem high-sensitivity mass spectrometry. Cognition was assessed using 3 neuropsychological tests at 3 time points, which were combined into a composite cognitive Z-score. Multivariable-adjusted linear mixed-effects models with random intercepts and slopes were used to estimate associations between 25(OH)D and cognitive change over 20 years. RESULTS: Compared to persons with sufficient 25(OH)D (≥30 ng/mL), those with deficient ( CONCLUSIONS: Lower concentrations of 25(OH)D measured in midlife were not significantly associated with more rapid cognitive decline over a 20-year follow-up period. The results of this prospective study are less susceptible to reverse causation than prior studies. |
DOI | 10.1159/000490912 |
Alternate Journal | Neuroepidemiology |
PubMed ID | 30092587 |
PubMed Central ID | PMC6240500 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States U01 HL096812 / HL / NHLBI NIH HHS / United States R01 HL103706 / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States R01 DK089174 / DK / NIDDK NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States R01 NS072243 / NS / NINDS NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States R25 NS065729 / NS / NINDS NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States K24 DK106414 / DK / NIDDK NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States |