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Chronic kidney disease measures and the risk of abdominal aortic aneurysm.

TitleChronic kidney disease measures and the risk of abdominal aortic aneurysm.
Publication TypeJournal Article
Year of Publication2018
AuthorsMatsushita K, Kwak L, Ballew SH, Grams ME, Selvin E, Folsom AR, Coresh JJ
Secondary AuthorsTang W
JournalAtherosclerosis
Volume279
Pagination107-113
Date Published2018 12
ISSN1879-1484
KeywordsAged, Albuminuria, Aortic Aneurysm, Abdominal, Biomarkers, Creatinine, Cross-Sectional Studies, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Incidence, Kidney, Male, Middle Aged, Prognosis, Prospective Studies, Renal Insufficiency, Chronic, Risk Assessment, Risk Factors, Time Factors, United States
Abstract

BACKGROUND AND AIMS: Despite its strong link to cardiovascular outcomes, the association of chronic kidney disease (CKD) with abdominal aortic aneurysm (AAA) has not been explicitly and comprehensively investigated.

METHODS: In 10,724 participants in the Atherosclerosis Risk in Communities Study (aged 53-75 years during 1996-1998), we evaluated the associations of two key CKD measures - estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (ACR) - with incident AAA (AAA diagnosis in outpatient, hospitalization discharge, or death records). Additionally, we performed a cross-sectional analysis for the CKD measures and ultrasound-based abdominal aortic diameter in 4258 participants during 2011-2013.

RESULTS: During a median follow-up of 13.9 years, 347 participants developed AAA. The demographically-adjusted hazard ratio (HR) was 4.44 (95% CI 1.58-12.49) for eGFR

CONCLUSIONS: Reduced eGFR and elevated albuminuria were independently associated with greater incidence of AAA and greater abdominal aortic diameter. Our results suggest the potential usefulness of CKD measures to identify persons at high risk of AAA and the need to investigate pathophysiological pathways linking CKD to AAA.

DOI10.1016/j.atherosclerosis.2018.08.043
Alternate JournalAtherosclerosis
PubMed ID30290962
PubMed Central IDPMC6295219
Grant ListHHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R01 HL103695 / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States