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Leisure-time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities Study.

TitleLeisure-time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2019
AuthorsPalta P, Sharrett ARichey, Deal JA, Evenson KR, Gabriel KPettee, Folsom AR, Gross AL, B Windham G, Knopman D, Mosley TH
Secondary AuthorsHeiss G
JournalAlzheimers Dement
Volume15
Issue2
Pagination273-281
Date Published2019 02
ISSN1552-5279
KeywordsAge Factors, Atherosclerosis, Cognition, Exercise, Female, Humans, Leisure Activities, Male, Middle Aged, Risk Factors
Abstract

INTRODUCTION: We tested the hypotheses that higher levels of and persistence of midlife leisure-time physical activity (LTPA) are associated long-term with lower cognitive decline and less incident dementia.

METHODS: A total of 10,705 participants (mean age: 60 years) had LTPA (no, low, middle, or high) measured in 1987-1989 and 1993-1995. LTPA was assessed in relation to incident dementia and 14-year change in general cognitive performance.

RESULTS: Over a median follow-up of 17.4 years, 1063 dementia cases were observed. Compared with no LTPA, high LTPA in midlife was associated with lower incidence of dementia (hazard ratio [95% confidence interval], 0.71 [0.61, 0.86]) and lower declines in general cognitive performance (-0.07 standard deviation difference [-0.12 to -0.04]). These associations were stronger when measured against persistence of midlife LTPA over 6 years.

DISCUSSION: LTPA is a readily modifiable factor associated inversely with long-term dementia incidence and cognitive decline.

DOI10.1016/j.jalz.2018.08.008
Alternate JournalAlzheimers Dement
PubMed ID30321503
PubMed Central IDPMC6368879
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
K01 AG050699 / AG / NIA NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
T32 HL007055 / HL / NHLBI NIH HHS / United States
K99 AG052830 / AG / NIA NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
R01 AG053938 / AG / NIA NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
L30 AG057117 / AG / NIA NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
K01 AG054693 / AG / NIA NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268200900020C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
R00 AG052830 / AG / NIA NIH HHS / United States