Title | Leisure-time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities Study. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Palta P, Sharrett ARichey, Deal JA, Evenson KR, Gabriel KPettee, Folsom AR, Gross AL, B Windham G, Knopman D, Mosley TH |
Secondary Authors | Heiss G |
Journal | Alzheimers Dement |
Volume | 15 |
Issue | 2 |
Pagination | 273-281 |
Date Published | 2019 02 |
ISSN | 1552-5279 |
Keywords | Age Factors, Atherosclerosis, Cognition, Exercise, Female, Humans, Leisure Activities, Male, Middle Aged, Risk Factors |
Abstract | INTRODUCTION: We tested the hypotheses that higher levels of and persistence of midlife leisure-time physical activity (LTPA) are associated long-term with lower cognitive decline and less incident dementia. METHODS: A total of 10,705 participants (mean age: 60 years) had LTPA (no, low, middle, or high) measured in 1987-1989 and 1993-1995. LTPA was assessed in relation to incident dementia and 14-year change in general cognitive performance. RESULTS: Over a median follow-up of 17.4 years, 1063 dementia cases were observed. Compared with no LTPA, high LTPA in midlife was associated with lower incidence of dementia (hazard ratio [95% confidence interval], 0.71 [0.61, 0.86]) and lower declines in general cognitive performance (-0.07 standard deviation difference [-0.12 to -0.04]). These associations were stronger when measured against persistence of midlife LTPA over 6 years. DISCUSSION: LTPA is a readily modifiable factor associated inversely with long-term dementia incidence and cognitive decline. |
DOI | 10.1016/j.jalz.2018.08.008 |
Alternate Journal | Alzheimers Dement |
PubMed ID | 30321503 |
PubMed Central ID | PMC6368879 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States U01 HL096812 / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States K01 AG050699 / AG / NIA NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States T32 HL007055 / HL / NHLBI NIH HHS / United States K99 AG052830 / AG / NIA NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States R01 AG053938 / AG / NIA NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States L30 AG057117 / AG / NIA NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States K01 AG054693 / AG / NIA NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States R01 HL070825 / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268200900020C / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States R00 AG052830 / AG / NIA NIH HHS / United States |