Title | Longer-term Lipid-lowering Drug Use and Risk of Incident and Fatal Prostate Cancer in Black and White Men in the ARIC Study. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Mondul AM, Joshu CE, Barber JR, Prizment AE, Bhavsar NA, Selvin E, Folsom AR |
Secondary Authors | Platz EA |
Journal | Cancer Prev Res (Phila) |
Volume | 11 |
Issue | 12 |
Pagination | 779-788 |
Date Published | 2018 12 |
ISSN | 1940-6215 |
Keywords | African Americans, Atherosclerosis, European Continental Ancestry Group, Follow-Up Studies, Health Status Disparities, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Incidence, Male, Middle Aged, Prospective Studies, Prostatic Neoplasms, Risk Assessment, Risk Factors, Survival Rate, Time Factors, United States |
Abstract | Lipid-lowering medications, particularly statins, may protect against aggressive prostate cancer. Fatal prostate cancer, the most clinically relevant outcome, remains understudied for this association. We prospectively studied lipid-lowering medication use and both incident and fatal prostate cancer in black and white men in the Atherosclerosis Risk in Communities (ARIC) study. A total of 6,518 men without cancer at visit 2 (1990-1992), the start of the statin era, were followed for prostate cancer incidence and death through 2012. Medication use was collected during study visits and telephone calls at up to nine time points during follow-up. Cox regression was used to estimate HR and 95% confidence intervals (CI) of total (white = 541, black = 259) and fatal (white = 56, black = 34) prostate cancer overall and by race. Lipid-lowering medication use was modeled as time-dependent current use or duration (never, |
DOI | 10.1158/1940-6207.CAPR-17-0396 |
Alternate Journal | Cancer Prev Res (Phila) |
PubMed ID | 30327368 |
PubMed Central ID | PMC6289799 |
Grant List | P30 CA006973 / CA / NCI NIH HHS / United States R01 DK089174 / DK / NIDDK NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States K24 DK106414 / DK / NIDDK NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States U01 CA164975 / CA / NCI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States K01 HL140146 / HL / NHLBI NIH HHS / United States |