|Title||Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Deal JA, Sharrett ARichey, Albert M, Bandeen-Roche K, Burgard S, Thomas SDavis, Gottesman RF, Knopman D, Mosley T, Klein B|
|Secondary Authors||Klein R|
|Date Published||2019 03|
|Keywords||African Americans, Aged, Atherosclerosis, Cognitive Dysfunction, Dementia, European Continental Ancestry Group, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Retinal Diseases, Retinal Vessels, Risk Factors|
INTRODUCTION: The easily-imaged retinal microvasculature may reflect the brain microvasculature and therefore be related to dementia.
METHODS: In a population-based study of 12,482 adults aged 50-73 years (22% African American), we estimated the relationship of retinal characteristics from fundus photography (1993-1995) with incident all-cause dementia (1993-1995 to 2011-2013) and with etiologic subtype of dementia/mild cognitive impairment (2011-13).
RESULTS: A total of 1259 (10%) participants developed dementia over a mean 15.6 years. Moderate/severe (vs. no) retinopathy (hazard ratio [HR], 1.86; 95% confidence interval [CI]: 1.36-2.55) and central retinal arteriolar equivalent (narrowest quartile vs. widest three quartiles; HR, 1.26; 95% CI: 1.09-1.45) were associated with all-cause dementia. Results were qualitatively stronger (but not statistically significantly different) in participants with diabetes. Retinopathy was associated with a joint outcome of cerebrovascular-related, but not Alzheimer's disease-related, dementia/mild cognitive impairment (HR, 2.29; 95% CI: 1.24-4.23).
DISCUSSION: Exploration of measures in the eye may provide surrogate indices of microvascular lesions relevant to dementia.
|Alternate Journal||Alzheimers Dement|
|PubMed Central ID||PMC6408967|
|Grant List||U01 HL096812 / HL / NHLBI NIH HHS / United States |
U01 HL096917 / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
K01 AG054693 / AG / NIA NIH HHS / United States
HHSN268201000021C / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States