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Neural correlates of domain-specific cognitive decline: The ARIC-NCS Study.

TitleNeural correlates of domain-specific cognitive decline: The ARIC-NCS Study.
Publication TypeJournal Article
Year of Publication2019
AuthorsSchneider ALC, Senjem ML, Wu A, Gross A, Knopman DS, Gunter JL, Schwarz CG, Mosley TH, Gottesman RF, Sharrett ARichey
Secondary AuthorsJack CR
JournalNeurology
Volume92
Issue10
Paginatione1051-e1063
Date Published2019 03 05
ISSN1526-632X
KeywordsAged, Brain, Cognitive Dysfunction, Dementia, Executive Function, Female, Gray Matter, Humans, Language, Longitudinal Studies, Magnetic Resonance Imaging, Male, Memory, Neuropsychological Tests, Organ Size, Prospective Studies
Abstract

OBJECTIVE: To evaluate the association of cognitive declines in the domains of memory, language, and executive function with brain gray matter (GM) volume in old age.

METHODS: This was a prospective study of 1,846 participants in the Atherosclerosis Risk in Communities (ARIC) Study who underwent 3T brain MRI scans in 2011 to 2013. Participants were categorized by cognitive domain performance trajectory over the prior 20 years (cut point to define decline: 20th percentile). Associations between GM volume and cognitive declines were assessed at the voxel level with voxel-based morphometry and at the regional level with atlas-defined GM volumes of specific regions of interest.

RESULTS: Participants were an average age of 76 years; 60% were female; and 28% were black. Participants in the top 20th percentile for decline in the memory domain had smaller GM volumes in the medial temporal lobe (-3.3%, 95% confidence interval [CI] -4.6% to -2.1%), amygdala (-2.7%, 95% CI -4.1% to -1.3%), entorhinal cortex (-4.1%, 95% CI -6.0% to -2.2%), and hippocampus (-3.8%, 95% CI -5.2% to -2.4%) compared to participants who were in the lowest 80th percentile for decline in all domains. In contrast, among participants who were in the top 20th percentile for decline in the language or executive function domains, GM volumes were smaller in more brain regions.

CONCLUSIONS: Declines in memory function were associated with brain volume loss in the medial temporal and hippocampal formations. Declines in language and executive function were associated with decreases in brain volumes across more noncontiguous brain regions.

DOI10.1212/WNL.0000000000007042
Alternate JournalNeurology
PubMed ID30728308
PubMed Central IDPMC6442014
Grant ListU01 HL096812 / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States