|Title||Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Walker KA, Gottesman RF, Wu A, Knopman DS, Gross AL, Mosley TH, Selvin E|
|Secondary Authors||B Windham G|
|Date Published||2019 03 12|
|Keywords||Aged, Aged, 80 and over, C-Reactive Protein, Cognition, Cognitive Dysfunction, Cohort Studies, Executive Function, Factor VIII, Female, Fibrinogen, Humans, Inflammation, Language, Leukocyte Count, Longitudinal Studies, Male, Memory, Middle Aged, von Willebrand Factor|
OBJECTIVE: To examine the association between systemic inflammation measured during midlife and 20-year cognitive decline.
METHODS: Within the Atherosclerosis Risk in Communities cohort study, inflammatory biomarkers were measured during middle adulthood. We created an inflammation composite score using 4 blood biomarkers measured at visit 1 (fibrinogen, white blood cell count, von Willebrand factor, and factor VIII); we measured C-reactive protein (CRP) at visit 2. Cognition was assessed over 3 visits spanning 20 years using measures of memory, executive function, and language.
RESULTS: A total of 12,336 participants (baseline age 56.8 [5.7], 21% black, 56% women) were included. After adjusting for demographic variables, vascular risk factors, and comorbidities, each standard deviation (SD) increase in midlife inflammation composite score was associated with an additional 20-year decline of -0.035 SD (95% confidence interval: -0.062 to -0.007) on the cognitive composite score. We found a similar association between each SD increase in midlife CRP level and additional 20-year cognitive decline (-0.038 SD, 95% confidence interval: -0.057 to -0.019). Participants with a midlife inflammation composite score in the top quartile had a 7.8% steeper cognitive decline, compared to participants in the lowest quartile; CRP in the top quartile was associated with an 11.6% steeper cognitive decline. In cognitive domain-specific analyses, elevated midlife inflammatory markers were most consistently associated with declines in memory. Results were similar after adjusting for attrition using inverse probability weighting.
CONCLUSIONS: Our findings highlight what may be an early pathogenic role for systemic inflammation as a driver of cognitive decline in the decades leading up to older adulthood.
|PubMed Central ID||PMC6511107|
|Grant List||U01 HL096812 / HL / NHLBI NIH HHS / United States |
T32 AG027668 / AG / NIA NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
K24 AG052573 / AG / NIA NIH HHS / United States