Title | Central and peripheral pulse wave velocity and subclinical myocardial stress and damage in older adults. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Liu S, Kim ED, Wu A, Meyer ML, Cheng S, Hoogeveen RC, Ballantyne CM, Tanaka H, Heiss G, Selvin E |
Secondary Authors | Matsushita K |
Journal | PLoS One |
Volume | 14 |
Issue | 2 |
Pagination | e0212892 |
Date Published | 2019 |
ISSN | 1932-6203 |
Keywords | Aged, Aged, 80 and over, Biomarkers, Cardiovascular Diseases, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Pulse Wave Analysis, Risk Factors, Troponin T, Vascular Stiffness |
Abstract | BACKGROUND: Arterial stiffness independently predicts cardiovascular disease. However, few studies have evaluated the associations of central and peripheral pulse wave velocity (PWV) with biomarkers of both myocardial stress (natriuretic peptide [NT-proBNP]) and damage (high-sensitivity cardiac troponin-T [hs-cTnT]) among persons without cardiac disease. METHODS: We examined 3,348 participants (67-90 years) without prevalent cardiac disease in the Atherosclerosis Risk in Communities (ARIC) Study (2011-13). The cross-sectional associations of PWV quartiles for central arterial segments (carotid-femoral, heart-carotid, heart-femoral) and peripheral artery (femoral-ankle) with NT-proBNP and hs-cTnT were evaluated accounting for potential confounders. RESULTS: Most PWV measures demonstrated J- or U-shaped associations with the two cardiac biomarkers. The highest (Q4) vs. second lowest (Q2) quartile of central PWV measures (carotid-femoral, heart-carotid, heart-femoral PWV) were associated with higher levels of NT-proBNP independently of demographic characteristics. The associations were less evident for hs-cTnT. These associations were attenuated after adjusting for traditional cardiovascular risk factors, but the heart-carotid PWV-NT-proBNP relationship remained borderline significant (difference in log-NT-proBNP = 0.08 [-0.01, 0.17] in Q4 vs. Q2, p = 0.07). Peripheral PWV demonstrated inverse associations. Higher values of NT-proBNP were seen in the lowest vs. second lowest quartile of all PWV measures. CONCLUSIONS: Central stiffness measures showed stronger associations with cardiac biomarkers (particularly NT-proBNP) than peripheral measures among older adults without cardiac disease. Our findings are consistent with the concept of ventricular-vascular coupling and suggest that central rather than peripheral arterial hemodynamics are more closely related to myocardial stress rather than damage. |
DOI | 10.1371/journal.pone.0212892 |
Alternate Journal | PLoS One |
PubMed ID | 30811490 |
PubMed Central ID | PMC6392306 |
Grant List | K24 DK106414 / DK / NIDDK NIH HHS / United States R01 AG053938 / AG / NIA NIH HHS / United States R01 HL134320 / HL / NHLBI NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States |