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Association of Atrial Fibrillation With White Matter Disease.

TitleAssociation of Atrial Fibrillation With White Matter Disease.
Publication TypeJournal Article
Year of Publication2019
AuthorsShao IYuefan, Power MC, Mosley T, Jack C, Gottesman RF, Chen LYee, Norby FL, Soliman EZ
Secondary AuthorsAlonso A
JournalStroke
Volume50
Issue4
Pagination989-991
Date Published2019 04
ISSN1524-4628
KeywordsAged, Aged, 80 and over, Atrial Fibrillation, Brain, Cognitive Dysfunction, Cross-Sectional Studies, Dementia, Female, Humans, Leukoencephalopathies, Magnetic Resonance Imaging, Male, White Matter
Abstract

Background and Purpose- Evidence suggests that atrial fibrillation (AF) is associated with increased risk of cognitive decline and dementia, even in the absence of stroke. White matter disease (WMD) is a potential mechanism linking AF to cognitive impairment. In this study, we explored the association between prevalent AF and WMD. Methods- We performed a cross-sectional analysis of participants attending the ARIC-NCS (Atherosclerosis Risk in Communities-Neurocognitive Study) in 2011 to 2013 who underwent brain magnetic resonance imaging. AF was ascertained from study visit electrocardiograms or prior hospitalization codes. Extent of WMD was defined by measures of white matter (WM) microstructural integrity and WM hyperintensity volume. Multivariable linear regression models were used to assess the association between AF and WMD. Results- Among 1899 participants (mean age, 76 years; 28% black; 60% women), 133 (7%) had prevalent AF. After multivariable adjustment, differences between participants with and without AF were -0.001 (95% CI, -0.006 to 0.004) for global WM fractional anisotropy, 0.031×10 mm/s (95% CI, -0.075 to 0.137) for global WM mean diffusivity, and 0.08 mm (95% CI, -0.14 to 0.30) for WM hyperintensity volume. Conclusions- The results suggest that there is no association between prevalent AF and WMD.

DOI10.1161/STROKEAHA.118.023386
Alternate JournalStroke
PubMed ID30879437
PubMed Central IDPMC6433530
Grant ListU01 HL096812 / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
16EIA26410001 / AHA / American Heart Association-American Stroke Association / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
K24 AG052573 / AG / NIA NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States