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Association of Head Injury with Brain Amyloid Deposition: The ARIC-PET Study.

TitleAssociation of Head Injury with Brain Amyloid Deposition: The ARIC-PET Study.
Publication TypeJournal Article
Year of Publication2019
AuthorsSchneider ALC, Selvin E, Liang M, Latour L, L Turtzo C, Koton S, Coresh JJ, Mosley T, Whitlow CT, Zhou Y, Wong DF, Ling G
Secondary AuthorsGottesman RF
JournalJ Neurotrauma
Date Published2019 09 01
KeywordsAged, Amyloid, Brain, Craniocerebral Trauma, Female, Humans, Male, Middle Aged, Positron-Emission Tomography

Our objective was to examine associations of head injury with total and regional brain amyloid deposition. We performed cross-sectional analyses of 329 non-demented participants (81 with prior head injury) in the Atherosclerosis Risk in Communities-Positron Emission Tomography (ARIC-PET) Study who underwent florbetapir PET imaging in 2012-2014. A history of head injury was defined by self-report or emergency department/hospitalization International Classification of Diseases, Ninth Revision codes. Generalized linear regression models adjusted for demographic, socioeconomic, and dementia/cardiovascular risk factors were used to estimate prevalence ratios (PRs; 95% confidence intervals [CIs]) for elevated (> 1.2) global and regional standard uptake value ratios (SUVRs). Mean age of participants was 76 years, 57% were women, and 43% were black. Head injury was associated with increased prevalence of elevated SUVR >1.2 globally (PR: 1.31; 95% CI: 1.19-1.57), as well as in the orbitofrontal cortex (PR: 1.23); (95% CI: 1.04-1.46), prefrontal cortex (PR: 1.18; 95% CI: 1.00-1.39), superior frontal cortex (PR: 1.24; 95% CI: 1.05-1.48), and posterior cingulate (PR: 1.26; 95% CI: 1.04-1.52). There also was evidence for a dose-response relationship, whereby a history of ≥1 head injury was associated with elevated SUVR >1.2 in the prefrontal cortex and superior frontal cortex compared with persons with a history of one head injury (all,  

Alternate JournalJ Neurotrauma
PubMed ID30963804
PubMed Central IDPMC6909743
Grant ListK24 AG052573 / AG / NIA NIH HHS / United States
P30 AG049638 / AG / NIA NIH HHS / United States
R01 AG040282 / AG / NIA NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States