Title | Relation of Isolated Systolic Hypertension and Pulse Pressure to High-Sensitivity Cardiac Troponin-T and N-Terminal pro-B-Type Natriuretic Peptide in Older Adults (from the Atherosclerosis Risk in Communities Study). |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Madan N, Lee AK, Matsushita K, Hoogeveen RC, Ballantyne CM, Selvin E |
Secondary Authors | McEvoy JW |
Journal | Am J Cardiol |
Volume | 124 |
Issue | 2 |
Pagination | 245-252 |
Date Published | 2019 07 15 |
ISSN | 1879-1913 |
Keywords | Atherosclerosis, Biomarkers, Blood Pressure, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Hypertension, Incidence, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Retrospective Studies, Risk Assessment, Risk Factors, Systole, Troponin T, United States |
Abstract | Isolated systolic hypertension (ISH) and elevated pulse pressure (PP) are common blood pressure (BP) abnormalities in older adults, reflect poor vascular compliance, and can signify risk for cardiovascular outcomes. We sought to characterize the associations of ISH and widened PP with high-sensitivity Troponin-T (hs-cTnT; a marker of myocardial damage) and N-terminal pro-B-type natriuretic peptide (NT-proBNP; a marker of hemodynamic stress) levels in older adults. We performed a cross-sectional analysis of 5,251 Atherosclerosis Risk in Communities (ARIC) study participants without heart failure who attended visit 5 (2011 to 2013). We used logistic regression to evaluate the association of ISH (systolic BP ≥140 mm Hg and diastolic BP |
DOI | 10.1016/j.amjcard.2019.04.030 |
Alternate Journal | Am J Cardiol |
PubMed ID | 31088661 |
PubMed Central ID | PMC6581585 |
Grant List | R01 DK089174 / DK / NIDDK NIH HHS / United States T32 HL007024 / HL / NHLBI NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States HHSN268201700004C / HL / NHLBI NIH HHS / United States R01 HL134320 / HL / NHLBI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States K24 DK106414 / DK / NIDDK NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States HHSN268201700005C / HL / NHLBI NIH HHS / United States HHSN268201700001C / HL / NHLBI NIH HHS / United States HHSN268201700003C / HL / NHLBI NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States |