|Title||Association between greater leg length and increased incidence of colorectal cancer: the atherosclerosis risk in communities (ARIC) study.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Onyeaghala G, Lutsey PL, Demerath EW, Folsom AR, Joshu CE, Platz EA|
|Secondary Authors||Prizment AE|
|Journal||Cancer Causes Control|
|Date Published||2019 Aug|
|Keywords||Atherosclerosis, Body Height, Cohort Studies, Colorectal Neoplasms, Female, Humans, Incidence, Leg, Male, Middle Aged, Risk Factors|
PURPOSE: Previous studies have reported that taller people have an increased risk of colorectal cancer (CRC). We examined the association of two height components-leg length and sitting height-with CRC risk in 14,532 individuals aged 45-64 years in the Atherosclerosis Risk in Communities study.
METHODS: Anthropometrics were measured at baseline (1987-1989). Incident CRC cases (n = 382) were ascertained from 1987 to 2012. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios for CRC and colon cancer across quintiles of sex-specific leg length and sitting height.
RESULTS: The highest (versus the lowest) quintile of leg length was associated with a 36% greater CRC risk (p-trend = 0.04), and 51% greater colon cancer risk (p-trend = 0.01). For the top four quintiles combined, risk was increased by 34% for CRC and by 45% for colon cancer versus the lowest quintile. Total height and sitting height were not significantly associated with CRC or colon cancer risk. A small number of cases (n = 57) limited our ability to conduct subgroup analyses for rectal cancer.
CONCLUSIONS: A positive association of leg length with CRC and colon cancer risk suggests that biological mechanisms leading to greater leg length during puberty may explain the association between taller height and CRC.
|Alternate Journal||Cancer Causes Control|
|PubMed Central ID||PMC6681820|
|Grant List||UL1 TR002494 / TR / NCATS NIH HHS / United States |
HHSN268201700002C / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
KL2 TR002492 / TR / NCATS NIH HHS / United States
HHSN268201700004C / HL / NHLBI NIH HHS / United States
U01 CA164975 / CA / NCI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
U01CA164975 / CA / NCI NIH HHS / United States
HHSN268201700005C / HL / NHLBI NIH HHS / United States
HHSN268201700001C / HL / NHLBI NIH HHS / United States
HHSN268201700003C / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States