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Prospective Association of Serum and Dietary Magnesium with Colorectal Cancer Incidence.

TitleProspective Association of Serum and Dietary Magnesium with Colorectal Cancer Incidence.
Publication TypeJournal Article
Year of Publication2019
AuthorsPolter EJ, Onyeaghala G, Lutsey PL, Folsom AR, Joshu CE, Platz EA
Secondary AuthorsPrizment AE
JournalCancer Epidemiol Biomarkers Prev
Volume28
Issue8
Pagination1292-1299
Date Published2019 08
ISSN1538-7755
KeywordsColorectal Neoplasms, Diet, Female, Follow-Up Studies, Humans, Incidence, Magnesium, Male, Middle Aged, Prospective Studies, Risk Factors, Sex Factors, United States
Abstract

BACKGROUND: Laboratory and epidemiologic research suggests a protective role of magnesium in colorectal cancer development. We estimated the associations of serum and dietary magnesium with colorectal cancer incidence in the Atherosclerosis Risk in Communities (ARIC) study.

METHODS: Serum magnesium concentration was measured in blood collected twice (1987-1989 and 1990-1992) and averaged. Dietary magnesium was assessed by food-frequency questionnaire administered twice (1987-1989 and 1993-1995) and averaged. For both dietary and serum magnesium, the averaged measures were categorized into quintiles for analysis. Analyses included 315 colorectal cancer cases among 13,009 participants for serum magnesium (followed for a median of 20.4 years), and 256 cases among 10,971 participants for dietary magnesium (followed for a median of 17.5 years). Cox proportional hazards regression was used to calculate multivariable-adjusted HRs and 95% confidence intervals (CI).

RESULTS: Multivariable-adjusted HRs (95% CI) of colorectal cancer for the highest four quintiles compared with the first quintile of serum magnesium were as follows: Q2: 0.70 (0.49-0.99); Q3: 0.68 (0.47-1.00); Q4: 0.87 (0.62-1.21); and Q5: 0.79 (0.57-1.11; = 0.04). An inverse association was present in females (HR for Q5 vs. Q1: 0.59, 95% CI: 0.36-0.98, = 0.01), but not males (HR for Q5 vs. Q1: 1.10, 95% CI: 0.67-1.79, = 0.92; = 0.34). Dietary magnesium was not statistically significantly associated with colorectal cancer risk.

CONCLUSIONS: Our study found a higher risk of colorectal cancer with lower serum magnesium among females, but not males.

IMPACT: If our findings are confirmed, maintaining adequate serum magnesium levels may be important for colorectal cancer prevention.

DOI10.1158/1055-9965.EPI-18-1300
Alternate JournalCancer Epidemiol Biomarkers Prev
PubMed ID31167754
PubMed Central IDPMC6677594
Grant ListP30 CA006973 / CA / NCI NIH HHS / United States
UL1 TR002494 / TR / NCATS NIH HHS / United States
HHSN268201700002C / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
KL2 TR002492 / TR / NCATS NIH HHS / United States
HHSN268201700004C / HL / NHLBI NIH HHS / United States
U01 CA164975 / CA / NCI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
HHSN268201700005C / HL / NHLBI NIH HHS / United States
HHSN268201700001C / HL / NHLBI NIH HHS / United States
HHSN268201700003C / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States