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Kidney Risk Variants and Cardiovascular Disease: An Individual Participant Data Meta-Analysis.

Title Kidney Risk Variants and Cardiovascular Disease: An Individual Participant Data Meta-Analysis.
Publication TypeJournal Article
Year of Publication2019
AuthorsGrams ME, Surapaneni A, Ballew SH, Appel LJ, Boerwinkle E, Boulware EL, Chen TK, Coresh JJ, Cushman M, Divers J, Gutierrez OM, Irvin MR, Ix JH, Kopp JB, Kuller LH, Langefeld CD, Lipkowitz MS, Mukamal KJ, Musani SK, Naik RP, Pajewski NM, Peralta CA, Tin A, Wassel CL, Wilson JG, Winkler CA, Young BA, Zakai NA
Secondary AuthorsFreedman BI
JournalJ Am Soc Nephrol
Volume30
Issue10
Pagination2027-2036
Date Published2019 10
ISSN1533-3450
KeywordsAfrican Americans, Apolipoprotein L1, Cardiovascular Diseases, Genetic Variation, Humans, Kidney Diseases, Risk Assessment
Abstract

BACKGROUND: Two coding variants in the apo L1 gene () are strongly associated with kidney disease in blacks. Kidney disease itself increases the risk of cardiovascular disease, but whether these variants have an independent direct effect on the risk of cardiovascular disease is unclear. Previous studies have had inconsistent results.

METHODS: We conducted a two-stage individual participant data meta-analysis to assess the association of kidney-risk variants with adjudicated cardiovascular disease events and death, independent of kidney measures. The analysis included 21,305 blacks from eight large cohorts.

RESULTS: Over 8.9┬▒5.0 years of follow-up, 2076 incident cardiovascular disease events occurred in the 16,216 participants who did not have cardiovascular disease at study enrollment. In fully-adjusted analyses, individuals possessing two kidney-risk variants had similar risk of incident cardiovascular disease (coronary heart disease, myocardial infarction, stroke and heart failure; hazard ratio 1.11, 95% confidence interval, 0.96 to 1.28) compared to individuals with zero or one kidney-risk variant. The risk of coronary heart disease, myocardial infarction, stroke and heart failure considered individually was also comparable by genotype. genotype was also not associated with death. There was no difference in adjusted associations by level of kidney function, age, diabetes status, or body-mass index.

CONCLUSIONS: In this large, two-stage individual participant data meta-analysis, kidney-risk variants were not associated with incident cardiovascular disease or death independent of kidney measures.

DOI10.1681/ASN.2019030240
Alternate JournalJ Am Soc Nephrol
PubMed ID31383730
PubMed Central IDPMC6779370
Grant ListK08 DK117068 / DK / NIDDK NIH HHS / United States
P30 DK079310 / DK / NIDDK NIH HHS / United States
R01 DK100446 / DK / NIDDK NIH HHS / United States
R01 DK108803 / DK / NIDDK NIH HHS / United States
R01 DK102134 / DK / NIDDK NIH HHS / United States