Title | Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Rawlings AM, Sharrett ARichey, Mosley TH, Wong DF, Knopman DS |
Secondary Authors | Gottesman RF |
Journal | J Alzheimers Dis |
Volume | 68 |
Issue | 2 |
Pagination | 517-521 |
Date Published | 2019 |
ISSN | 1875-8908 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Brain, Cognitive Reserve, Cohort Studies, Educational Status, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography, Prospective Studies |
Abstract | We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical standardized uptake value ratio (SUVR) >1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer's disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis. |
DOI | 10.3233/JAD-180785 |
Alternate Journal | J Alzheimers Dis |
PubMed ID | 30775981 |
PubMed Central ID | PMC6443418 |
Grant List | U01 HL096812 / HL / NHLBI NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States T32 HL007024 / HL / NHLBI NIH HHS / United States R01 AG040282 / AG / NIA NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States R01 HL070825 / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States K24 AG052573 / AG / NIA NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States |