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Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life.

TitleCognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life.
Publication TypeJournal Article
Year of Publication2019
AuthorsRawlings AM, Sharrett ARichey, Mosley TH, Wong DF, Knopman DS
Secondary AuthorsGottesman RF
JournalJ Alzheimers Dis
Volume68
Issue2
Pagination517-521
Date Published2019
ISSN1875-8908
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Brain, Cognitive Reserve, Cohort Studies, Educational Status, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography, Prospective Studies
Abstract

We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical standardized uptake value ratio (SUVR) >1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer's disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis.

DOI10.3233/JAD-180785
Alternate JournalJ Alzheimers Dis
PubMed ID30775981
PubMed Central IDPMC6443418
Grant ListU01 HL096812 / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
R01 AG040282 / AG / NIA NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
K24 AG052573 / AG / NIA NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States